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http://hdl.handle.net/1942/16699
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DC Field | Value | Language |
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dc.contributor.author | VISCONTI, Laura | - |
dc.contributor.author | NELISSEN, Katherine | - |
dc.contributor.author | Deckx, Laura | - |
dc.contributor.author | van den Akker, Marjan | - |
dc.contributor.author | Adriaensen, Wim | - |
dc.contributor.author | Daniels, Liesbeth | - |
dc.contributor.author | Mathei, Cathy | - |
dc.contributor.author | LINSEN, Loes | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | Buntinx, Frank | - |
dc.date.accessioned | 2014-04-28T10:16:32Z | - |
dc.date.available | 2014-04-28T10:16:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | BIOMARKERS IN MEDICINE, 8 (2), p. 297-306 | - |
dc.identifier.issn | 1752-0363 | - |
dc.identifier.uri | http://hdl.handle.net/1942/16699 | - |
dc.description.abstract | Through their tumor-promoting and/or tumor-suppressive properties, cytokines can influence progression of cancer. We systematically reviewed the current literature on the prognostic value of the circulating cytokines IL-1α/β, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF-β and IFN-γ to predict overall and disease-free survival in any type of cancer patients. PubMed was systematically searched and based on eligibility assessment using our five criteria of the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) checklist, six unique studies were reviewed. Elevated IL-6 and IL-10 levels seem independently associated with worse prognosis in terms of overall and disease-free survival. The prognostic value of IL-1α/β, IL-8, IL-12, TNF-α, TGF-β and IFN-γ could not be demonstrated. The small number of selected studies underlines the need for large well-designed prospective studies, using the REMARK checklist as a guideline, to determine which cytokines have prognostic value on survival in cancer patients. | - |
dc.description.sponsorship | This systematic review was supported by Interreg IV border regions Flanders - The Netherlands (grant number IVA-VLANED-3.46). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | - |
dc.language.iso | en | - |
dc.subject.other | cytokines; mortality; neoplasms; prognosis | - |
dc.title | Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 306 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 297 | - |
dc.identifier.volume | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Visconti, L (reprint author), Hasselt Univ, Fac Med & Life Sci, Campus Diepenbeek,Martelarenlaan 42, B-3500 Hasselt, Belgium laura.visconti@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.2217/bmm.13.122 | - |
dc.identifier.isi | 000331212400025 | - |
item.fulltext | With Fulltext | - |
item.contributor | VISCONTI, Laura | - |
item.contributor | NELISSEN, Katherine | - |
item.contributor | Deckx, Laura | - |
item.contributor | van den Akker, Marjan | - |
item.contributor | Adriaensen, Wim | - |
item.contributor | Daniels, Liesbeth | - |
item.contributor | Mathei, Cathy | - |
item.contributor | LINSEN, Loes | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | Buntinx, Frank | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2015 | - |
item.fullcitation | VISCONTI, Laura; NELISSEN, Katherine; Deckx, Laura; van den Akker, Marjan; Adriaensen, Wim; Daniels, Liesbeth; Mathei, Cathy; LINSEN, Loes; HELLINGS, Niels; STINISSEN, Piet & Buntinx, Frank (2014) Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients. In: BIOMARKERS IN MEDICINE, 8 (2), p. 297-306. | - |
crisitem.journal.issn | 1752-0363 | - |
crisitem.journal.eissn | 1752-0371 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
suppl_tables.pdf Restricted Access | 208.85 kB | Adobe PDF | View/Open Request a copy | |
ViscontiL_BMM.pdf Restricted Access | Published version | 799.9 kB | Adobe PDF | View/Open Request a copy |
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