Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16755
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dc.contributor.authorOGUNJIMI, Benson-
dc.contributor.authorSmits, Evelien-
dc.contributor.authorHeynderickx, Steven-
dc.contributor.authorVan den Bergh, Johan-
dc.contributor.authorBilcke, Joke-
dc.contributor.authorJansens, Hilde-
dc.contributor.authorMalfait, Ronald-
dc.contributor.authorRamet, Jose-
dc.contributor.authorMaecker, Holden T.-
dc.contributor.authorCools, Nathalie-
dc.contributor.authorBeutels, Philippe-
dc.contributor.authorVan Damme, Pierre-
dc.date.accessioned2014-04-30T09:58:33Z-
dc.date.available2014-04-30T09:58:33Z-
dc.date.issued2014-
dc.identifier.citationCLINICAL AND VACCINE IMMUNOLOGY, 21 (3), p. 417-426-
dc.identifier.issn1556-6811-
dc.identifier.urihttp://hdl.handle.net/1942/16755-
dc.description.abstractReexposure to viruses is assumed to strengthen humoral and cellular immunity via the secondary immune response. We studied the effects of frequent exposure to viral infectious challenges on immunity. Furthermore, we assessed whether repetitive exposures to varicella-zoster virus (VZV) elicited persistently high immune responses. Blood samples from 11 pediatricians and matched controls were assessed at 3 time points and 1 time point, respectively. Besides the assessment of general immunity by means of measuring T-cell subset percentages, antibody titers and gamma interferon (IFN-γ)/interleukin 2 (IL-2)-producing T-cell percentages against adenovirus type 5 (AdV-5), cytomegalovirus (CMV), tetanus toxin (TT), and VZV were determined. Pediatricians had lower levels of circulating CD4+-naive T cells and showed boosting of CD8+ effector memory T cells. Although no effect on humoral immunity was seen, repetitive exposures to VZV induced persistently higher percentages of IFN-γ-positive T cells against all VZV antigens tested (VZV glycoprotein E [gE], VZV intermediate-early protein 62 [IE62], and VZV IE63) than in controls. T cells directed against latency-associated VZV IE63 benefitted the most from natural exogenous boosting. Although no differences in cellular or humoral immunity were found between the pediatricians and controls for AdV-5 or TT, we did find larger immune responses against CMV antigens in pediatricians. Despite the high infectious burden, we detected a robust and diverse immune system in pediatricians. Repetitive exposures to VZV have been shown to induce a stable increased level of VZV-specific cellular but not humoral immunity. Based on our observations, VZV IE63 can be considered a candidate for a zoster vaccine.-
dc.description.sponsorshipThe human CMV pp65 peptide pool was obtained through the NIH AIDS Research and Reference Reagent Program (Division of AIDS, NIAID, NIH). This work was supported by grants of the Research Foundation Flanders (project grant, predoctoral fellowship to B.O., postdoctoral fellowships to J. B. and N.C.), the Hercules Foundation-Belgium, and the University of Antwerp (predoctoral fellowship to J.V.D.B.). The funders had no role in study design, data collection or analysis, the decision to publish, or preparation of the manuscript.-
dc.language.isoen-
dc.rightsCopyright © 2014, American Society for Microbiology. All Rights Reserved.-
dc.titleInfluence of Frequent Infectious Exposures on General and Varicella-Zoster Virus-Specific Immune Responses in Pediatricians-
dc.typeJournal Contribution-
dc.identifier.epage426-
dc.identifier.issue3-
dc.identifier.spage417-
dc.identifier.volume21-
local.bibliographicCitation.jcatA1-
dc.description.notesOgunjimi, B (reprint author), Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Ctr Hlth Econ Res & Modeling Infect Dis, B-2020 Antwerp, Belgium. benson.ogunjimi@uantwerp.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1128/CVI.00818-13-
dc.identifier.isi000332036900019-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
item.validationecoom 2015-
item.contributorOGUNJIMI, Benson-
item.contributorSmits, Evelien-
item.contributorHeynderickx, Steven-
item.contributorVan den Bergh, Johan-
item.contributorBilcke, Joke-
item.contributorJansens, Hilde-
item.contributorMalfait, Ronald-
item.contributorRamet, Jose-
item.contributorMaecker, Holden T.-
item.contributorCools, Nathalie-
item.contributorBeutels, Philippe-
item.contributorVan Damme, Pierre-
item.fullcitationOGUNJIMI, Benson; Smits, Evelien; Heynderickx, Steven; Van den Bergh, Johan; Bilcke, Joke; Jansens, Hilde; Malfait, Ronald; Ramet, Jose; Maecker, Holden T.; Cools, Nathalie; Beutels, Philippe & Van Damme, Pierre (2014) Influence of Frequent Infectious Exposures on General and Varicella-Zoster Virus-Specific Immune Responses in Pediatricians. In: CLINICAL AND VACCINE IMMUNOLOGY, 21 (3), p. 417-426.-
crisitem.journal.issn1556-6811-
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