Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/16760
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | DE BOEVER, Patrick | - |
dc.contributor.author | Wens, Britt | - |
dc.contributor.author | Forcheh, Anyiawung Chiara | - |
dc.contributor.author | Reynders, Hans | - |
dc.contributor.author | Nelen, Vera | - |
dc.contributor.author | KLEINJANS, J. | - |
dc.contributor.author | Van Larebeke, Nicolas | - |
dc.contributor.author | VERBEKE, Geert | - |
dc.contributor.author | VALKENBORG, Dirk | - |
dc.contributor.author | Schoeters, Greet | - |
dc.date.accessioned | 2014-04-30T10:33:38Z | - |
dc.date.available | 2014-04-30T10:33:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | GENOMICS, 103 (1), p. 31-39 | - |
dc.identifier.issn | 0888-7543 | - |
dc.identifier.uri | http://hdl.handle.net/1942/16760 | - |
dc.description.abstract | A repeated measures microarray design with 22 healthy, non-smoking volunteers (aging 32 ± 5 years) was set up to study transcriptome profiles in whole blood samples. The results indicate that repeatable data can be obtained with highwithin-subject correlation. Probes that could discriminate between individuals are associated with immune and inflammatory functions. When investigating possible time trends in the microarray data, we have found no differential expression within a sampling period (within-season effect). Differential expression was observed between sampling seasons and the data suggest a weak response of genes related to immune system functioning. Finally, a high number of probes showed significant season-specific expression variability within subjects. Expression variability increased in springtime and there was an association of the probe list with immune system functioning. Our study suggests that the blood transcriptome of healthy individuals is reproducible over a time period of several months. | - |
dc.description.sponsorship | The project was funded by the Environment, Nature and Energy Department of the Flemish government (contract number LNE/OL200700049/8031/M&G). Britt Wens was supported by a VITO PhD-fellowship. We thank Karen Hollanders for her excellent technical skills during the execution of the project. The medical department of the Belgian Nuclear Research Centre is acknowledged for their support in collecting the blood samples. | - |
dc.language.iso | en | - |
dc.rights | © 2013 Elsevier Inc. All rights reserved. | - |
dc.subject.other | whole blood; transcriptome; gene expression variability; immune system; biomonitoring; public health | - |
dc.title | Characterization of the peripheral blood transcriptome in a repeated measures design using a panel of healthy individuals | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 39 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 31 | - |
dc.identifier.volume | 103 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | De Boever, P (reprint author), Flemish Inst Technol Res VITO, Unit Environm Risk & Hlth, Ind Vlasmeer 7, B-2400 Mol, Belgium patrick.deboever@vito.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.ygeno.2013.11.006 | - |
dc.identifier.isi | 000333512800004 | - |
item.validation | ecoom 2015 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | DE BOEVER, Patrick; Wens, Britt; Forcheh, Anyiawung Chiara; Reynders, Hans; Nelen, Vera; KLEINJANS, J.; Van Larebeke, Nicolas; VERBEKE, Geert; VALKENBORG, Dirk & Schoeters, Greet (2014) Characterization of the peripheral blood transcriptome in a repeated measures design using a panel of healthy individuals. In: GENOMICS, 103 (1), p. 31-39. | - |
item.fulltext | With Fulltext | - |
item.contributor | DE BOEVER, Patrick | - |
item.contributor | Wens, Britt | - |
item.contributor | Forcheh, Anyiawung Chiara | - |
item.contributor | Reynders, Hans | - |
item.contributor | Nelen, Vera | - |
item.contributor | KLEINJANS, J. | - |
item.contributor | Van Larebeke, Nicolas | - |
item.contributor | VERBEKE, Geert | - |
item.contributor | VALKENBORG, Dirk | - |
item.contributor | Schoeters, Greet | - |
crisitem.journal.issn | 0888-7543 | - |
crisitem.journal.eissn | 1089-8646 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
de boever 1.pdf Restricted Access | Published version | 1.27 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
10
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
13
checked on May 9, 2024
Page view(s)
106
checked on Sep 6, 2022
Download(s)
90
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.