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http://hdl.handle.net/1942/16765
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DC Field | Value | Language |
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dc.contributor.author | Goeminne, P. C. | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | RUTTENS, David | - |
dc.contributor.author | Seys, S. | - |
dc.contributor.author | Dupont, L. J. | - |
dc.date.accessioned | 2014-05-05T11:30:01Z | - |
dc.date.available | 2014-05-05T11:30:01Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | RESPIRATORY MEDICINE, 108 (2), p. 287-296 | - |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | http://hdl.handle.net/1942/16765 | - |
dc.description.abstract | Introduction: There is limited data on mortality and associated morbidity in non-cystic fibrosis bronchiectasis (NCFB). Our aim was to analyze the overall mortality for all newly diagnosed patients from June 2006 onwards and to evaluate risk factors for mortality in this cohort. Methods: 245 patients who had a new diagnosis of NCFB between June 2006 and October 2012 at the University Hospital of Leuven, Belgium, were included in the analysis. Death was analyzed until end of November 2013. All patients had chest HRCT scan confirming the presence of bronchiectatic lesions and had symptoms of chronic productive cough. Univariate and multivariate Cox proportional hazard survival regression analysis was used to estimate hazard ratios (HR) and their 95% confidence intervals (CI) of variables possibly predicting mortality. Results: Overall mortality in NCFB patients who had a median follow-up of 5.18 years was 20.4%. Patients with NCFB and associated chronic obstructive pulmonary disease (COPD) had a mortality of 55% in that period. Univariate analysis showed higher mortality according to age, gender, smoking history, Pseudomonas aeruginosa status, spirometry, radiological extent, total number of sputum bacteria and underlying etiology. Multivariate analysis showed significant higher mortality with increasing age (HR Z 1.045; p Z 0.004), with increasing number of lobes affected (HR Z 1.53; p Z 0.009) and when patients had COPD associated NCFB (HR Z 2.12; p Z 0.038). The majority of the 50 deaths were respiratory related (n Z 29; 58%). | - |
dc.language.iso | en | - |
dc.rights | © 2014 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | chronic colonization; pseudomonas aeruginosa; COPD; bronchiectasis; survival; mortality | - |
dc.title | Mortality in non-cystic fibrosis bronchiectasis: A prospective cohort analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 296 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 287 | - |
dc.identifier.volume | 108 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Goeminne, PC (reprint author), Univ Hosp Gasthuisberg, Dept Lung Dis, Herestr 49, B-3000 Louvain, Belgium. pieter.goeminne@student.kuleuven.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.rmed.2013.12.015 | - |
dc.identifier.isi | 000331917000007 | - |
item.fullcitation | Goeminne, P. C.; NAWROT, Tim; RUTTENS, David; Seys, S. & Dupont, L. J. (2014) Mortality in non-cystic fibrosis bronchiectasis: A prospective cohort analysis. In: RESPIRATORY MEDICINE, 108 (2), p. 287-296. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2015 | - |
item.contributor | Goeminne, P. C. | - |
item.contributor | NAWROT, Tim | - |
item.contributor | RUTTENS, David | - |
item.contributor | Seys, S. | - |
item.contributor | Dupont, L. J. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0954-6111 | - |
crisitem.journal.eissn | 1532-3064 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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goeminne 1.pdf | Published version | 409.9 kB | Adobe PDF | View/Open |
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