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Title: Strategies to manage hepatitis C virus (HCV) disease burden
Authors: Wedemeyer, H.
Duberg, A. S.
Buti, M.
Rosenberg, W. M.
Frankova, S.
Esmat, G.
Ormeci, N.
Van Vlierberghe, H.
Gschwantler, M.
Akarca, U.
Aleman, S.
Balik, I.
Berg, T.
Bihl, F.
Bilodeau, M.
Blasco, A. J.
Brandao Mello, C. E.
Bruggmann, P.
Calinas, F.
Calleja, J. L.
Cheinquer, H.
Christensen, P. B.
Clausen, M.
Coelho, H. S. M.
Cornberg, M.
Cramp, M. E.
Dore, G. J.
Doss, W.
El-Sayed, M. H.
Ergor, G.
Estes, C.
Falconer, K.
Felix, J.
Ferraz, M. L. G.
Ferreira, P. R.
Garcia-Samaniego, J.
Gerstoft, J.
Giria, J. A.
Goncales, F. L., Jr.
Guimaraes Pessoa, M.
Hezode, C.
Hindman, S. J.
Hofer, H.
Husa, P.
Idilman, R.
Kaberg, M.
Kaita, K. D. E.
Kautz, A.
Kaymakoglu, S.
Krajden, M.
Krarup, H.
Laleman, W.
Lavanchy, D.
Lazaro, P.
Marinho, R. T.
Marotta, P.
Mauss, Stefan
Mendes Correa, M. C.
Moreno, C.
Muellhaupt, B.
Myers, R. P.
Nemecek, V.
Ovrehus, A. L. H.
Parkes, J.
Peltekian, K. M.
Ramji, A.
Razavi, H.
Reis, N.
Roberts, S. K.
Roudot-Thoraval, F.
Ryder, S. D.
Sarmento-Castro, R.
Sarrazin, C.
Semela, D.
Sherman, M.
Shiha, G. E.
Sperl, J.
Starkel, P.
Stauber, R. E.
Thompson, A. J.
Urbanek, P.
Van Damme, P.
van Thiel, I.
VANDIJCK, Dominique 
Vogel, W.
Waked, I.
Weis, N.
Wiegand, J.
Yosry, A.
Zekry, A.
Negro, F.
Sievert, W.
Gower, E.
Issue Date: 2014
Source: JOURNAL OF VIRAL HEPATITIS, 21 (S1), p. 60-89
Abstract: The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCVrelated morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3–5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.
Notes: Wedemeyer, H (reprint author), Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str, D-30625 Hannover, Germany.
Keywords: diagnosis; disease burden; epidemiology; HCV; hepatitis C; incidence; mortality; prevalence; scenarios; treatment
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ISSN: 1352-0504
e-ISSN: 1365-2893
DOI: 10.1111/jvh.12249
ISI #: 000333893200004
Rights: © 2014 John Wiley & Sons Ltd
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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