Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16828
Title: Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors
Authors: THEWISSEN, Kristof 
Nuyts, Amber H.
Deckx, Nathalie
VAN WIJMEERSCH, Bart 
Nagels, Guy
D'hooghe, Marie
Willekens, Barbara
Cras, Patrick
Eijnde, Bert O. 
Goossens, Herman
Van Tendeloo, Viggo F. I.
STINISSEN, Piet 
Berneman, Zwi N.
HELLINGS, Niels 
Cools, Nathalie
Issue Date: 2014
Source: MULTIPLE SCLEROSIS JOURNAL, 20 (5), p. 548-557
Abstract: Background: The role of the adaptive immune system and more specifically T cells in the pathogenesis of multiple sclerosis (MS) has been studied extensively. Emerging evidence suggests that dendritic cells (DCs), which are innate immune cells, also contribute to MS. Objectives: This study aimed to characterize circulating DC populations in MS and to investigate the contribution of MS-associated genetic risk factors to DCs. Methods: Ex vivo analysis of conventional (cDCs) and plasmacytoid DCs (pDCs) was carried out on peripheral blood of MS patients (n = 110) and age- and gender-matched healthy controls (n = 112). Results: Circulating pDCs were significantly decreased in patients with chronic progressive MS compared to relapsing–remitting MS and healthy controls. While no differences in cDCs frequency were found between the different study groups, HLA-DRB1*1501+ MS patients and patients not carrying the protective IL-7Rα haplotype 2 have reduced frequencies of circulating cDCs and pDCs, respectively. MS-derived DCs showed enhanced IL-12p70 production upon TLR ligation and had an increased expression of the migratory molecules CCR5 and CCR7 as well as an enhanced in vitro chemotaxis. Conclusion: DCs in MS are in a pro-inflammatory state, have a migratory phenotype and are affected by genetic risk factors, thereby contributing to pathogenic responses.
Keywords: dendritic cells; multiple sclerosis; costimulatory molecules; migration; MS-associated genetic risk factors
Document URI: http://hdl.handle.net/1942/16828
ISSN: 1352-4585
e-ISSN: 1477-0970
DOI: 10.1177/1352458513505352
ISI #: 000333690400008
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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