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http://hdl.handle.net/1942/16910
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DC Field | Value | Language |
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dc.contributor.author | GEURTS, Nathalie | - |
dc.contributor.author | Becker-Pauly, Christoph | - |
dc.contributor.author | Martens, Erik | - |
dc.contributor.author | Proost, Paul | - |
dc.contributor.author | Van den Steen, Philippe E. | - |
dc.contributor.author | Stöcker, Walter | - |
dc.contributor.author | OPDENAKKER, Ghislain | - |
dc.date.accessioned | 2014-06-18T07:48:37Z | - |
dc.date.available | 2014-06-18T07:48:37Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | FEBS LETTERS, 586 (24), p. 4264-4269 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/1942/16910 | - |
dc.description.abstract | Meprin alpha and beta, members of the astacin family of zinc metalloproteinases, are unique plasma membrane and secreted proteases known to cleave a wide range of biological substrates involved in inflammation, cancer and fibrosis. In this study, we identified proMMP-9 as a novel substrate and show that aminoterminal meprin-mediated clipping improves the activation kinetics of proMMP-9 by MMP-3, an efficient activator of proMMP-9. Interestingly, the NH2-terminus LVLFPGDL, generated by incubation with meprin alpha, is identical to the form produced in conditioned media from human neutrophils and monocytes. Hence, this meprin-mediated processing and enhancement of MMP-9 activation kinetics may have biological relevance in the context of in vivo inflammatory processes. Structured summary of protein interactions: Meprin beta cleaves MMP-9 by enzymatic study (View interaction) Meprin beta cleaves MMP-9 by zymography (View interaction) Meprin alpha cleaves MMP-9 by zymography (View interaction) Meprin alpha cleaves MMP-9 by enzymatic study (View interaction) (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | Fund for Scientific Research-Flanders (FWO-Vlaanderen); Geconcerteerde OnderzoeksActies (grant number GOA 2012-017); Deutsche Forschungsgemeinschaft (DFG)(grant numbers BE 4086/1-2; SFB877); Cluster of Excellence "Inflammation at Interfaces" | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.subject.other | Meprin; ProMMP-9; Aminoterminal cleavage | - |
dc.subject.other | biochemistry & molecular biology; biophysics; cell biology | - |
dc.title | Meprins process matrix metalloproteinase-9 ( MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3 | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4269 | - |
dc.identifier.issue | 24 | - |
dc.identifier.spage | 4264 | - |
dc.identifier.volume | 586 | - |
local.format.pages | 6 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Geurts, Nathalie; Martens, Erik; Van den Steen, Philippe E.; Opdenakker, Ghislain] Univ Louvain, Rega Inst Med Res, Immunobiol Lab, B-3000 Louvain, Belgium. [Becker-Pauly, Christoph] Univ Kiel, Unit Degrad Protease Web, Inst Biochem, D-24118 Kiel, Germany. [Proost, Paul] Univ Louvain, Rega Inst Med Res, Lab Mol Immunol, B-3000 Louvain, Belgium. [Stoecker, Walter] Johannes Gutenberg Univ Mainz, Inst Zool, Dept Cell & Matrix Biol, D-55128 Mainz, Germany. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.febslet.2012.10.033 | - |
dc.identifier.isi | 000312004400003 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | GEURTS, Nathalie; Becker-Pauly, Christoph; Martens, Erik; Proost, Paul; Van den Steen, Philippe E.; Stöcker, Walter & OPDENAKKER, Ghislain (2012) Meprins process matrix metalloproteinase-9 ( MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3. In: FEBS LETTERS, 586 (24), p. 4264-4269. | - |
item.contributor | GEURTS, Nathalie | - |
item.contributor | Becker-Pauly, Christoph | - |
item.contributor | Martens, Erik | - |
item.contributor | Proost, Paul | - |
item.contributor | Van den Steen, Philippe E. | - |
item.contributor | Stöcker, Walter | - |
item.contributor | OPDENAKKER, Ghislain | - |
crisitem.journal.issn | 0014-5793 | - |
crisitem.journal.eissn | 1873-3468 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Geurts, 2012.pdf Restricted Access | 776.08 kB | Adobe PDF | View/Open Request a copy |
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