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Title: | Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis | Authors: | Gomez, Alejandro M. VANHEEL, Annelies Losen, Mario Molenaar, Peter C. DE BAETS, Marc NOBEN, Jean-Paul HELLINGS, Niels Martinez-Martinez, Pilar |
Issue Date: | 2013 | Publisher: | ELSEVIER SCIENCE BV | Source: | JOURNAL OF NEUROIMMUNOLOGY, 261 (1-2), p. 141-145 | Abstract: | Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscles proteomic profile at different stages of experimental autoimmune myasthenia gravis (EAMG). We identified twenty-two differentially expressed proteins, mainly related to metabolic and stress-response pathways. Interestingly, these identified proteins have also been associated with other contraction-impairing muscle pathologies (e.g. inclusion body myositis), suggesting a similar response of the muscle to such conditions. (C) 2013 Elsevier B.V. All rights reserved. | Notes: | [Gomez, Alejandro M.; Losen, Mario; Molenaar, Peter C.; De Baets, Marc H.; Martinez-Martinez, Pilar] Maastricht Univ, Sch Mental Hlth & Neurosci, Div Neurosci, NL-6200 MD Maastricht, Netherlands. [Vanheel, Annelies; De Baets, Marc H.; Noben, Jean-Paul; Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3500 Hasselt, Belgium. [Vanheel, Annelies; De Baets, Marc H.; Noben, Jean-Paul; Hellings, Niels] Transnatl Univ Limburg, Sch Life Sci, B-3500 Hasselt, Belgium. | Keywords: | myasthenia gravis; muscle proteomics; 2D-DIGE; autoimmunity;Myasthenia gravis; Muscle proteomics; 2D-DIGE; Autoimmunity | Document URI: | http://hdl.handle.net/1942/16986 | ISSN: | 0165-5728 | e-ISSN: | 1872-8421 | DOI: | 10.1016/j.jneuroim.2013.05.008 | ISI #: | 000323459400020 | Rights: | © 2013 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
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