Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17046
Title: Genetic Variation in Immunoglobulin G Receptor Affects Survival After Lung Transplantation
Authors: Ruttens, D.
Verleden, S. E.
Goeminne, P. C.
Vandermeulen, E.
Wauters, E.
COX, Bianca 
Vos, R.
Van Raemdonck, D. E.
LAMBRECHTS, Danny 
Vanaudenaerde, B. M.
Verleden, G. M.
Issue Date: 2014
Publisher: WILEY-BLACKWELL
Source: AMERICAN JOURNAL OF TRANSPLANTATION, 14 (7), p. 1672-1677
Abstract: Chronic rejection remains the most important complication after lung transplantation (LTx). There is mounting evidence that both rheumatoid arthritis and chronic rejection share similar inflammatory mechanisms. As genetic variants in the FCGR2A gene that encodes the immunoglobulin gamma receptor (IgGR) have been identified in rheumatoid arthritis, we investigated the relationship between a genetic variant in the IgGR gene and chronic rejection and mortality after LTx. Recipient DNA from blood or explant lung tissue of 418 LTx recipients was evaluated for the IgGR (rs12746613) polymorphism. Multivariate analysis was carried out, correcting for several co-variants. In total, 216 patients had the CC-genotype (52%), 137 had the CT-genotype (33%) and 65 had the TT-genotype (15%). Univariate analysis demonstrated higher mortality in the TT-genotype compared with both other genotypes (p<0.0001). Multivariate analysis showed that the TT-genotype had worse survival compared with the CC-genotype (hazard ratio [HR]=2.26, p=0.0002) but no significance was observed in the CT-genotype (HR=1.32, p=0.18). No difference was seen for chronic rejection. The TT-genotype demonstrated more respiratory infections (total, p=0.037; per patient, p=0.0022) compared with the other genotypes. A genetic variant in the IgGR is associated with higher mortality and more respiratory infections, although not with increased prevalence of chronic rejection, after LTx.
Notes: [Ruttens, D.; Verleden, S. E.; Goeminne, P. C.; Vandermeulen, E.; Vos, R.; Van Raemdonck, D. E.; Vanaudenaerde, B. M.; Verleden, G. M.] Katholieke Univ Leuven, Lung Transplant Unit, Lab Pneumol, Univ Hosp Gasthuisberg Leuven, Leuven, Belgium. [Wauters, E.; Lambrechts, D.] VIB, VRC, Leuven, Belgium. [Wauters, E.; Lambrechts, D.] Katholieke Univ Leuven, Lab Translat Genet, Dept Oncol, Leuven, Belgium. [Cox, B.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium.
Keywords: FCGR2A; genetics; IgG; lung transplantation; mortality; respiratory infections;FCGR2A; genetics; IgG; lung transplantation; mortality; respiratory infections
Document URI: http://hdl.handle.net/1942/17046
ISSN: 1600-6135
e-ISSN: 1600-6143
DOI: 10.1111/ajt.12745
ISI #: 000338024700028
Rights: © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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