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http://hdl.handle.net/1942/17053
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DC Field | Value | Language |
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dc.contributor.author | PROVOST, Eline | - |
dc.contributor.author | Chaumont, Agnès | - |
dc.contributor.author | KICINSKI, Michal | - |
dc.contributor.author | COX, Bianca | - |
dc.contributor.author | Fierens, Frans | - |
dc.contributor.author | Bernard, Alfred | - |
dc.contributor.author | NAWROT, Tim | - |
dc.date.accessioned | 2014-07-30T09:21:51Z | - |
dc.date.available | 2014-07-30T09:21:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | ENVIRONMENT INTERNATIONAL, 68, p. 66-70 | - |
dc.identifier.issn | 0160-4120 | - |
dc.identifier.uri | http://hdl.handle.net/1942/17053 | - |
dc.description.abstract | Background: Studies in populations have shown that particulate air pollution is associated with changes in lung function in adolescents. Objective: We investigated the effect of short- and long-term exposure to particulate matter (PM10) on the pulmonary health of adolescents, using serum lung club cell secretory protein (Clara) (CC16) as a biomarker for respiratory epithelium integrity. Methods: We measured serum CC16 in 825 adolescents (57% girls, mean age: 15 years). Short-term and long-term exposure to ambient PM10 was estimated for each participant's home address using a kriging interpolation method. To explore the association between PM10 and serum CC16 we applied restricted cubic splines with 5 knots located at the 5th, 25th, 50th, 75th and 95th percentiles of the PM10, distribution. The explorative analyses showed a change in the slope of this association, after which a change-point analysis was performed. Results: After adjustment for potential covariates, the analysis showed strong associations between PM10 concentrations, averaged over the week preceding the clinical examination, and serum CC16 levels. Each 5 mu g/m(3) increase in mean PM10 concentration in the week before the clinical examination was associated with a substantial increase of 0.52 mu g/l (95% confidence interval: 0.31 to 0.73; p < 0.0001) in serum CC16 levels. The association appears nonlinear with a flattening out of the slope at mean week PM10 levels above 37 mu g/m(3). There was no evidence of an association between long-term exposure to PM10 and serum CC16 concentrations. Conclusions: Our findings suggest that short-term exposure to particulate air pollution may compromise the integrity of the lung epithelium and lead to increased epithelial barrier permeability in the lungs of adolescents, even at low concentrations. | - |
dc.description.sponsorship | Belgian science policy under the Science for Sustainable Development program (grant number SD/HE/01); Flemish Scientific fund (grant number 1.2.506.07.N.00/G.0.919.10.N.10); EU program 'ENVIRONAGE' (grant number ERC-2012-StG310898); Ph. D. fellowship of the Research Foundation-Flanders (FWO); VITO-FWO Ph. D. fellowship | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.rights | © 2014 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | Club cell secretory protein (Clara); Particulate air pollution; Dose-response | - |
dc.subject.other | Club cell secretory protein (Clara); particulate air pollution; dose–response | - |
dc.title | Serum levels of club cell secretory protein (Clara) and short- and long-term exposure to particulate air pollution in adolescents | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 70 | - |
dc.identifier.spage | 66 | - |
dc.identifier.volume | 68 | - |
local.format.pages | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Provost, Eline B.; Kicinski, Michal; Cox, Bianca; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. [Provost, Eline B.] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Mol, Belgium. [Chaumont, Agnes; Bernard, Alfred] Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol, B-1200 Brussels, Belgium. [Fierens, Frans] Belgian Interreg Environm Agcy, Brussels, Belgium. [Nawrot, Tim S.] Leuven Univ, KU Leuven, Dept Publ Hlth Occupat & Environm Med, Leuven, Belgium. | - |
local.publisher.place | OXFORD | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.envint.2014.03.011 | - |
dc.identifier.isi | 000337874300008 | - |
item.validation | ecoom 2015 | - |
item.contributor | PROVOST, Eline | - |
item.contributor | Chaumont, Agnès | - |
item.contributor | KICINSKI, Michal | - |
item.contributor | COX, Bianca | - |
item.contributor | Fierens, Frans | - |
item.contributor | Bernard, Alfred | - |
item.contributor | NAWROT, Tim | - |
item.accessRights | Restricted Access | - |
item.fullcitation | PROVOST, Eline; Chaumont, Agnès; KICINSKI, Michal; COX, Bianca; Fierens, Frans; Bernard, Alfred & NAWROT, Tim (2014) Serum levels of club cell secretory protein (Clara) and short- and long-term exposure to particulate air pollution in adolescents. In: ENVIRONMENT INTERNATIONAL, 68, p. 66-70. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0160-4120 | - |
crisitem.journal.eissn | 1873-6750 | - |
Appears in Collections: | Research publications |
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provost 1.pdf Restricted Access | Published version | 604.84 kB | Adobe PDF | View/Open Request a copy |
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