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Title: A systematic review and meta-regression analysis of mivacurium for tracheal intubation
Authors: Vanlinthout, L. E. H.
Mesfin, S. H.
HENS, Niel 
Vanacker, B. F.
Robertson, E. N.
Booij, L. H. D. J.
Issue Date: 2014
Source: ANAESTHESIA, 69 (12), pag. 1377-1387
Abstract: We systematically reviewed factors associated with intubation conditions in randomised controlled trials of mivacurium, using random-effects meta-regression analysis. We included 29 studies of 1050 healthy participants. Four factors explained 72.9% of the variation in the probability of excellent intubation conditions: mivacurium dose, 24.4%; opioid use, 29.9%; time to intubation and age together, 18.6%. The odds ratio (95% CI) for excellent intubation was 3.14 (1.65–5.73) for doubling the mivacurium dose, 5.99 (2.14–15.18) for adding opioids to the intubation sequence, and 6.55 (6.01–7.74) for increasing the delay between mivacurium injection and airway insertion from 1 to 2 min in subjects aged 25 years and 2.17 (2.01–2.69) for subjects aged 70 years, p < 0.001 for all. We conclude that good conditions for tracheal intubation are more likely by delaying laryngoscopy after injecting a higher dose of mivacurium with an opioid, particularly in older people.
Notes: Correspondence to: L. E. H. Vanlinthout Email: *Presented at the 3rd joint Statistical Meeting, organised by the Deutsche Arbeitsgemeinschaft Statistik (DAGStat), March 2013, Freiburg, Germany. Accepted: 27 May 2014
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ISSN: 0003-2409
e-ISSN: 1365-2044
DOI: 10.1111/anae.12786
ISI #: 000345215400012
Rights: © 2014 The Association of Anaesthetists of Great Britain and Ireland.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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