Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17078
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dc.contributor.authorMerabishvili, Maia-
dc.contributor.authorVandenheuvel, D.-
dc.contributor.authorKropinski, A.M.-
dc.contributor.authorMast, J.-
dc.contributor.authorDe Vos, D.-
dc.contributor.authorVerbeken, G.-
dc.contributor.authorNOBEN, Jean-Paul-
dc.contributor.authorLavigne, R.-
dc.contributor.authorVaneechoutte, M.-
dc.contributor.authorPirnay, J.P.-
dc.date.accessioned2014-08-25T14:42:43Z-
dc.date.available2014-08-25T14:42:43Z-
dc.date.issued2014-
dc.identifier.citationPloS one, 9 (8) (ART N° e104853)-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/1942/17078-
dc.description.abstractBased on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further characterization. The complete genomes of the two phages were analyzed. Both phages are characterized by broad host range and essential features of potential therapeutic phages, such as short latent period (27 and 21 min, respectively), high burst size (125 and 145, respectively), stability of activity in liquid culture and low frequency of occurrence of phage-resistant mutant bacterial cells. Genomic analysis showed that while Acibel004 represents a novel bacteriophage with resemblance to some unclassified Pseudomonas aeruginosa phages, Acibel007 belongs to the well-characterized genus of the Phikmvlikevirus. The newly isolated phages can serve as potential candidates for phage cocktails to control A. baumannii infections.-
dc.description.sponsorshipThis work was supported by the Royal Higher Institute for Defense of Belgium (grant MED 12). The authors would like to acknowledge the Research community “Phagebiotics” (WO.022.09) grant from the FWO Vlaanderen. The research of DV was funded by a Ph.D. grant of the Agency for Innovation by Science and Technology (IWT) Flanders. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.-
dc.language.isoen-
dc.rights© 2014 Merabishvili et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.titleCharacterization of Newly Isolated Lytic Bacteriophages Active against Acinetobacter baumannii.-
dc.typeJournal Contribution-
dc.identifier.issue8-
dc.identifier.volume9-
local.format.pages11-
local.bibliographicCitation.jcatA1-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnre104853-
dc.identifier.doi10.1371/journal.pone.0104853-
dc.identifier.isi000341105100106-
item.fulltextWith Fulltext-
item.contributorMerabishvili, Maia-
item.contributorVandenheuvel, D.-
item.contributorKropinski, A.M.-
item.contributorMast, J.-
item.contributorDe Vos, D.-
item.contributorVerbeken, G.-
item.contributorNOBEN, Jean-Paul-
item.contributorLavigne, R.-
item.contributorVaneechoutte, M.-
item.contributorPirnay, J.P.-
item.fullcitationMerabishvili, Maia; Vandenheuvel, D.; Kropinski, A.M.; Mast, J.; De Vos, D.; Verbeken, G.; NOBEN, Jean-Paul; Lavigne, R.; Vaneechoutte, M. & Pirnay, J.P. (2014) Characterization of Newly Isolated Lytic Bacteriophages Active against Acinetobacter baumannii.. In: PloS one, 9 (8) (ART N° e104853).-
item.accessRightsClosed Access-
crisitem.journal.issn1932-6203-
crisitem.journal.eissn1932-6203-
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