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http://hdl.handle.net/1942/17114
Title: | Prevention of central line-associated bloodstream infections through quality improvement interventions: a systematic review and meta-analysis | Authors: | Blot, Koen BERGS, Jochen Vogelaers, Dirk Blot, Stijn VANDIJCK, Dominique |
Issue Date: | 2014 | Source: | CLINICAL INFECTIOUS DISEASES, 59 (1), p. 96-105 | Abstract: | This systematic review and meta-analysis examines the impact of quality improvement interventions on central line–associated bloodstream infections in adult intensive care units. Studies were identified through Medline and manual searches (1995–June 2012). Random-effects meta-analysis obtained pooled odds ratios (ORs) and 95% confidence intervals (CIs). Meta-regression assessed the impact of bundle/checklist interventions and high baseline rates on intervention effect. Forty-one before–after studies identified an infection rate decrease (OR, 0.39 [95% CI, .33–.46]; P < .001). This effect was more pronounced for trials implementing a bundle or checklist approach (P = .03). Furthermore, meta-analysis of 6 interrupted time series studies revealed an infection rate reduction 3 months postintervention (OR, 0.30 [95% CI, .10–.88]; P = .03). There was no difference in infection rates between studies with low or high baseline rates (P = .18). These results suggest that quality improvement interventions contribute to the prevention of central line–associated bloodstream infections. Implementation of care bundles and checklists appears to yield stronger risk reductions. | Keywords: | central line–associated bloodstream infection; catheter-related bloodstream infection; quality improvement intervention; meta-analysis | Document URI: | http://hdl.handle.net/1942/17114 | ISSN: | 1058-4838 | e-ISSN: | 1537-6591 | DOI: | 10.1093/cid/ciu239 | ISI #: | 000339665000019 | Rights: | © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
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Clinical Infectious Diseases 2014 Blot.pdf | 591.64 kB | Adobe PDF | View/Open |
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