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Title: Genetic Variation in Caveolin-1 Affects Survival After Lung Transplantation
Authors: Vandermeulen, Elly
Ruttens, David
Verleden, Stijn E.
VOS, Robin 
Van Raemdonck, Dirk E.
Kastelijn, Elisabeth A.
Wauters, Els
Lambrechts, Diether
COX, Bianca 
Verleden, Geert M.
Vanaudenaerde, Bart M.
Issue Date: 2014
Source: TRANSPLANTATION, 98 (3), p. 354-359
Abstract: Background. Caveolin-1 (CAV-1), a structural protein of the cell membrane, is involved in tissue homeostasis, inflammation, oxidative stress, microbial clearance, and fibrosis. Methods. We investigated a genetic predisposition of the CAV-1 gene on survival, acute and chronic rejection, lymphocytic bronchiolitis (LB), and respiratory infection after lung transplantation (LTx). Results. In 503 of 568 patients, the CAV-1 (rs3807989) polymorphism was successfully determined; 92 had the AA, 234 the AG, and 177 the GG genotype. Patients with the GG genotype had a decreased mortality with a adjusted hazard ratio of 0.72 (CI=0.53-0.98; P=0.034), but no association was found with chronic rejection, LB, acute rejection, or respiratory infections, although significantly less patients with the GG genotype died of infections (P=0.029). Airway neutrophilia (P=0.047) and systemic C-reactive protein (CRP, P=0.034) were decreased over time in the GG carriers compared to carriers of the A allele. Conclusion. We conclude that the GG genotype of CAV-1 is protective, associated with a decreased overall mortality but not with acute or chronic rejection, LB, and respiratory infections after LTx. The decreased mortality was linked with less infections of any kind and also lower systemic CRP, and airway neutrophils were observed, suggesting an overall decreased susceptibility for infectious complications in carriers of the GG genotype.
Notes: [Vandermeulen, Elly; Ruttens, David; Verleden, Stijn E.; Vos, Robin; Van Raemdonck, Dirk E.; Verleden, Geert M.; Vanaudenaerde, Bart M.] Katholieke Univ Leuven, Leuven Lung Transplant Grp, B-3000 Leuven, Belgium. [Vandermeulen, Elly; Ruttens, David; Verleden, Stijn E.; Vos, Robin; Van Raemdonck, Dirk E.; Verleden, Geert M.; Vanaudenaerde, Bart M.] UZ Leuven, Leuven, Belgium. [Kastelijn, Elisabeth A.] St Anthonius Hosp, Ctr Interstitial Lung Dis, Nieuwegein, Netherlands. [Wauters, Els; Lambrechts, Diether] Katholieke Univ Leuven, Lab Translat Genet, Dept Oncol, B-3000 Leuven, Belgium. [Wauters, Els; Lambrechts, Diether] VIB, VRC, Leuven, Belgium. [Nawrot, Tim S.; Cox, Bianca] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Dept Publ Hlth, B-3000 Leuven, Belgium.
Keywords: Caveolin-1; Lung transplantation; Chronic rejection
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ISSN: 0041-1337
e-ISSN: 1534-6080
DOI: 10.1097/TP.0000000000000058
ISI #: 000340381100025
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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