Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/17180
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hermans, Kris | - |
dc.contributor.author | Van den Plas, Dave | - |
dc.contributor.author | Kerimova, Sabina | - |
dc.contributor.author | CARLEER, Robert | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | Weyenberg, Wim | - |
dc.contributor.author | Ludwig, Annick | - |
dc.date.accessioned | 2014-09-25T08:51:19Z | - |
dc.date.available | 2014-09-25T08:51:19Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, 472 (1-2), p. 10-19 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | http://hdl.handle.net/1942/17180 | - |
dc.description.abstract | Ocular chitosan films were prepared in order to prolong ocular delivery of cyclosporine A. The mucoadhesive films were prepared using the solvent casting evaporation method. A 24 full factorial design was used to evaluate the effect of 4 preparation parameters on the film thickness, swelling index and mechanical properties. Moreover, uniformity of content and in vitro drug release were investigated. Possible interactions between the film excipients were studied by FTIR analysis. In vitro experiments were performed in order to evaluate the cytotoxicity and anti-inflammatory activity of the chitosan films. Film thickness, water uptake, mechanical properties and in vitro release of cyclosporine A were dependent on film composition, especially on the amount of plasticizer. Lower drug release was measured from chitosan films containing a higher amount of plasticizer as glycerol decreased the swelling of chitosan films. FTIR spectra suggest a reorganization of hydrogen bonds between chitosan chains in the presence of glycerol and cyclodextrins. None of the film formulations showed significant cytotoxicity as compared to the negative control using human epithelial cells (HaCaT). Cyclosporine A dispersed in the various film formulations remained anti-inflammatorily active as significant suppression of interleukin-2 secretion in concanavalin A stimulated Jurkat T cells was measured. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2014 Elsevier B.V. All rights reserved. | - |
dc.subject.other | chitosan; films; ocular; cyclosporine A | - |
dc.subject.other | Chitosan; Films; Ocular; Cyclosporine A | - |
dc.title | Development and characterization of mucoadhesive chitosan films for ophthalmic delivery of cyclosporine A | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 19 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 10 | - |
dc.identifier.volume | 472 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Hermans, Kris; Van den Plas, Dave; Kerimova, Sabina; Weyenberg, Wim; Ludwig, Annick] Univ Antwerp, Dept Pharmaceut Sci, Lab Pharmaceut Technol & Biopharm, B-2610 Antwerp, Belgium. [Carleer, Robert; Adriaensens, Peter] Hasselt Univ, Dept Chem, Inst Mat Res IMO, Diepenbeek, Belgium. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.ijpharm.2014.06.017 | - |
dc.identifier.isi | 000340328400002 | - |
item.fullcitation | Hermans, Kris; Van den Plas, Dave; Kerimova, Sabina; CARLEER, Robert; ADRIAENSENS, Peter; Weyenberg, Wim & Ludwig, Annick (2014) Development and characterization of mucoadhesive chitosan films for ophthalmic delivery of cyclosporine A. In: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 472 (1-2), p. 10-19. | - |
item.validation | ecoom 2015 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Hermans, Kris | - |
item.contributor | Van den Plas, Dave | - |
item.contributor | Kerimova, Sabina | - |
item.contributor | CARLEER, Robert | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | Weyenberg, Wim | - |
item.contributor | Ludwig, Annick | - |
crisitem.journal.issn | 0378-5173 | - |
crisitem.journal.eissn | 1873-3476 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hermans 1.pdf Restricted Access | Published version | 1.12 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
46
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
60
checked on May 16, 2024
Page view(s)
92
checked on Aug 9, 2022
Download(s)
84
checked on Aug 9, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.