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http://hdl.handle.net/1942/17186
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DC Field | Value | Language |
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dc.contributor.author | Croes, Kim | - |
dc.contributor.author | Den Hond, Elly | - |
dc.contributor.author | BRUCKERS, Liesbeth | - |
dc.contributor.author | Loots, Ilse | - |
dc.contributor.author | Morrens, Bert | - |
dc.contributor.author | Nelen, Vera | - |
dc.contributor.author | Colles, Ann | - |
dc.contributor.author | Schoeters, Greet | - |
dc.contributor.author | Sioen, Isabelle | - |
dc.contributor.author | Covaci, Adrian | - |
dc.contributor.author | Vandermarken, Tara | - |
dc.contributor.author | Van Larebeke, Nicolas | - |
dc.contributor.author | Baeyens, Willy | - |
dc.date.accessioned | 2014-09-26T10:56:24Z | - |
dc.date.available | 2014-09-26T10:56:24Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | ENVIRONMENT INTERNATIONAL, 71, p. 20-28 | - |
dc.identifier.issn | 0160-4120 | - |
dc.identifier.uri | http://hdl.handle.net/1942/17186 | - |
dc.description.abstract | Background: In 2007, the second cycle of the Flemish human biomonitoring survey started, with a main focus on 14-15 year-old adolescents. Objectives: The main objectives were generating reference values for exposure markers, determining the pollution pressure in industrial hotspots and establishing dose-effect relationships between exposure to pollutants and hormone levels, sexual development, asthma and allergy, genotoxic and hematological markers. Methods: Geometric means with 95% confidence intervals (Cl) were calculated for a reference population of 200 14-15 year-old adolescents. Stepwise multiple regression analyses with correction for confounders and covariates were performed to establish dose-effect relationships. Results: Geometric mean concentrations (with 95% Cl) of 49.6 (45.7, 53.8), 70.8 (63.6, 78.8) and 8.34 (7.76, 8.97) ng g(-1) lipid for the sum of PCB 138,153 and 180, p,p'-DDE and HCB were respectively 23%, 26% and 60% lower than those obtained five years earlier. Geometric mean concentrations of 108 (101, 114) and 32.1 (30.1, 34.2) pg CALUX-BEQ g(-1) lipid were observed for the PCDD/Fs and dioxin-like PCBs, respectively. Multiple dose-effect relationships were observed between POPs and several effect markers, including positive (boys) and negative (girls) associations with data on sexual development and positive associations with asthma, animal allergy and free thyroxine (boys and girls). Conclusions: Our findings suggest that chlorinated POP concentrations are decreasing over time and that even relatively low concentrations are associated with biological effects. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This study was commissioned, financed and steered by the Ministry of the Flemish Community (Department of Economics, Science and Innovation; Flemish Agency for Care and Health; and Department of Environment, Nature and Energy). Isabelle Sioen is financially supported by the Research Foundation - Flanders (grant no.: 1.2.683.11.N.00). We gratefully acknowledge the collaboration of the selected Flemish schools, the (psycho-medical) centers for guidance of pupils and all participating adolescents and their parents. | - |
dc.language.iso | en | - |
dc.rights | © 2014 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | chlorinated POPs; FLEHS II; dose-effect; hormones; human biomonitoring; sexual development | - |
dc.title | Monitoring chlorinated persistent organic pollutants in adolescents in Flanders (Belgium): Concentrations, trends and dose-effect relationships (FLEHS II) | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 28 | - |
dc.identifier.spage | 20 | - |
dc.identifier.volume | 71 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Croes, K (reprint author),Vrije Univ Brussel, Dept Analyt Environm & Geochem, Pl Laan 2, B-1050 Brussels, Belgium. kim.croes@vub.ac.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.envint.2014.05.022 | - |
dc.identifier.isi | 000341745100003 | - |
item.fullcitation | Croes, Kim; Den Hond, Elly; BRUCKERS, Liesbeth; Loots, Ilse; Morrens, Bert; Nelen, Vera; Colles, Ann; Schoeters, Greet; Sioen, Isabelle; Covaci, Adrian; Vandermarken, Tara; Van Larebeke, Nicolas & Baeyens, Willy (2014) Monitoring chlorinated persistent organic pollutants in adolescents in Flanders (Belgium): Concentrations, trends and dose-effect relationships (FLEHS II). In: ENVIRONMENT INTERNATIONAL, 71, p. 20-28. | - |
item.validation | ecoom 2015 | - |
item.contributor | Croes, Kim | - |
item.contributor | Den Hond, Elly | - |
item.contributor | BRUCKERS, Liesbeth | - |
item.contributor | Loots, Ilse | - |
item.contributor | Morrens, Bert | - |
item.contributor | Nelen, Vera | - |
item.contributor | Colles, Ann | - |
item.contributor | Schoeters, Greet | - |
item.contributor | Sioen, Isabelle | - |
item.contributor | Covaci, Adrian | - |
item.contributor | Vandermarken, Tara | - |
item.contributor | Van Larebeke, Nicolas | - |
item.contributor | Baeyens, Willy | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0160-4120 | - |
crisitem.journal.eissn | 1873-6750 | - |
Appears in Collections: | Research publications |
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croes 1.pdf Restricted Access | Published version | 269.01 kB | Adobe PDF | View/Open Request a copy |
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