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Title: | Ethical issues raised by whole genome sequencing | Authors: | PINXTEN, Wim Howard, Heidi Carmen |
Issue Date: | 2014 | Publisher: | ELSEVIER SCI LTD | Source: | BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY, 28 (2), p. 269-279 | Abstract: | While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of implementing WGS and WES. Nevertheless, the already known ethical issues, both in research and in clinical practice are diverse and complex and should be addressed properly presently. Herein, we discuss the ethical aspects of WGS and WES by particularly focussing on three overlapping themes: (1) informed consent, (2) data handling, and (3) the return of results. (C) 2014 Elsevier Ltd. All rights reserved. | Notes: | [Pinxten, Wim] Hasselt Univ, Fac Med & Life Sci, B-3500 Hasselt, Belgium. [Howard, Heidi Carmen] Radboud Univ Nijmegen, Med Ctr, IQhealthcare, NL-6500 NB Nijmegen, Netherlands. [Howard, Heidi Carmen] Uppsala Univ, Ctr Res Eth & Bioeth, SE-75122 Uppsala, Sweden. wim.pinxten@uhasselt.be; heidi.howard@mail.mcgill.ca | Keywords: | medical ethics; next generation sequencing; whole genome sequencing;Medical ethics; Next generation sequencing; Whole genome sequencing | Document URI: | http://hdl.handle.net/1942/17201 | ISSN: | 1521-6918 | e-ISSN: | 1532-1916 | DOI: | 10.1016/j.bpg.2014.02.004 | ISI #: | 000336705600006 | Rights: | © 2014 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
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