Protective effect of Zn²⁺ on heavy metal-induced reproductive toxicity

Abstract

The potential protective effect of zinc on the toxicity of arsenic, cadmium, copper, and nickel on the reproductive ability of Caenorhabditis elegans was investigated. Heavy metals have been addressed as toxic to different organ systems, including the reproductive system. During their evolution, organisms have developed several detoxification systems such as glutathione, metallothioneins, heat shock proteins, and transporters to defend themselves. Zinc is a trace element with well-known antioxidant properties that is tightly controlled. It is hypothesized that zinc reduces metal-induced oxidative stress, resulting in beneficial effects on the reproductive system.