Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17611
Title: Synthesis of biodegradable polymers via thiol-ene click polymerization
Authors: RAMAKERS, Gijs 
Advisors: JUNKERS, Tanja
ETHIRAJAN, Anitha
Issue Date: 2014
Publisher: tUL
Abstract: Biodegradable polymers can be used in variable applications within the field of biomedical sciences such as drug delivery systems, scaffolding, sutures and other. To produce these structures a novel and efficient method is explored to synthesize new materials with superior characteristics that may replace existing polymers in the future. In this project polymer networks are synthesized using thiol-ene click step growth polymerization. The used non-radical thiol-ene Michael addition is a fast reaction with high yields, which proceeds at room temperature with small amounts of catalyst, a tertiary phosphine. For the purpose of this thiol-ene step growth polymerization a dithiol homotelechelic polystyrene polymer is synthesized via RAFT polymerization using a bifunctional RAFT-agent (BiDoPAT) and subsequent aminolysis of the RAFT end groups. The resulting polymer is successfully conjugated with acrylic linkers (Mn of 7000 and tailing towards 100000 g'mol-1). By using acrylic linkers biodegradability is introduced via its ester moieties, which are spread throughout the entire molecule. A Baylis-Hillman step growth polymerization is a different method to produce polymers containing ester and accessible vinyl functionalities. The latter can be exploited to crosslink the residual Baylis-Hillman polymers. Furthermore a preliminary study was carried out using a suspension technique to synthesize degradable particles. The characteristics of the above mentioned polymers can be further tuned depending on the product's fate
Notes: master in de biomedische wetenschappen-bio-elektronica en nanotechnologie
Document URI: http://hdl.handle.net/1942/17611
Category: T2
Type: Theses and Dissertations
Appears in Collections:Master theses

Files in This Item:
File Description SizeFormat 
09283032013254.pdf2.7 MBAdobe PDFView/Open
Show full item record

Page view(s)

10
checked on May 26, 2022

Download(s)

4
checked on May 26, 2022

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.