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Title: Impact of traffic related air pollution indicators on non-cystic fibrosis bronchiectasis mortality: a cohort analysis
Authors: Goeminne, Pieter C.
Nemery, Ben
Dupont, Lieven J.
Issue Date: 2014
Abstract: Background: Mortality in non-cystic fibrosis bronchiectasis (NCFB) is known to be influenced by a number of factors such as gender, age, smoking history and Pseudomonas aeruginosa, but the impact of traffic related air pollution indicators on NCFB mortality is unknown. Methods: We followed 183 patients aged 18 to 65 years with a HRCT proven diagnosis of NCFB and typical symptoms, who had visited the outpatient clinic at the University Hospital of Leuven, Belgium, between June 2006 and October 2012. We estimated hazard ratios (HR) for mortality in relation to proximity of the home to major roads and traffic load, adjusting for relevant covariables (age, gender, disease severity, chronic macrolide use, smoking history, socioeconomic status and Pseudomonas aeruginosa colonization status). Results: Fifteen out of the 183 included patients died during the observation period. Residential proximity to a major road was associated with the risk of dying with a HR 0.28 (CI 95% 0.10-0.77; p = 0.013) for a tenfold increase in distance to a major road. Mortality was also associated with distance-weighted traffic density within 100 meters (HR for each tenfold increase in traffic density 3.80; CI 95% 1.07-13.51; p = 0.04) and 200 meters from the patient's home address (HR for each tenfold increase in traffic density 4.14; CI 95% 1.13-15.22; p = 0.032). Conclusion: Traffic-related air pollution appears to increase the risk of dying in patients with NCFB.
Notes: [Goeminne, Pieter C.; Dupont, Lieven J.] Univ Hosp Leuven, Dept Resp Dis, B-3000 Leuven, Belgium. [Bijnens, Esmee; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Nemery, Ben; Nawrot, Tim S.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Lab Lung Toxicol, Leuven, Belgium.
Keywords: non-cystic fibrosis bronchiectasis; pollution; traffic; road; mortality;Non-cystic fibrosis bronchiectasis; Pollution; Traffic; Road; Mortality
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e-ISSN: 1465-993X
DOI: 10.1186/s12931-014-0108-z
ISI #: 000341606800001
Rights: © 2014 Goeminne et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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