Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17762
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dc.contributor.authorDe Prins, Sofie-
dc.contributor.authorMarcucci, Francesco-
dc.contributor.authorSensi, Laura-
dc.contributor.authorVan de Mieroop, Els-
dc.contributor.authorNelen, Vera-
dc.contributor.authorNAWROT, Tim-
dc.contributor.authorSchoeters, Greet-
dc.contributor.authorKoppen, Gudrun-
dc.date.accessioned2014-11-06T13:13:14Z-
dc.date.available2014-11-06T13:13:14Z-
dc.date.issued2014-
dc.identifier.citationBIOMARKERS, 19 (6), p. 481-487-
dc.identifier.issn1354-750X-
dc.identifier.urihttp://hdl.handle.net/1942/17762-
dc.description.abstractRhinitis and asthma are the most common respiratory diseases in children. We assessed whether airway inflammation markers were associated with nasal allergies and self-reported symptoms of wheeze and rhinitis in 130 children 6-12 year old in an epidemiological context. Independent of sex and age, the fraction of exhaled nitric oxide (FeNO) and nasal mast cell (MC) activation (tryptase >= 5 ng/mL) were positively associated with wheeze, rhinitis and with nasal allergy. Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH, 8-isoprostane, interleukin-1 beta) were not associated with symptoms or with nasal allergy. In conclusion, FeNO and nasal tryptase reflect allergic inflammation in the respiratory system.-
dc.description.sponsorshipThe HEAPS study was funded by the Flemish Environment Agency (VMM), the Flemish Administration of Environment, Nature and Energy (LNE) and the Flemish Agency for Care and Health (VAZG). Sofie De Prins was supported by a VITO PhD scholarship. The authors report no declarations of interest.-
dc.language.isoen-
dc.publisherINFORMA HEALTHCARE-
dc.subject.otherEosinophil cationic protein; exhaled breath condensate; mast cells; Rhinostick-
dc.subject.otherEosinophil cationic protein; exhaled breath condensate; mast cells; Rhinostick-
dc.titleExhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children-
dc.typeJournal Contribution-
dc.identifier.epage487-
dc.identifier.issue6-
dc.identifier.spage481-
dc.identifier.volume19-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notes[De Prins, Sofie; Schoeters, Greet] Vlaamse Instelling Technol Onderzoek, Environm Risk & Hlth Unit, Boeretang, Belgium. [De Prins, Sofie; Schoeters, Greet; Koppen, Gudrun] Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, B-2020 Antwerp, Belgium. [Marcucci, Francesco; Sensi, Laura] Spin Off ATRP Srl, Allerg Tests Res & Prod Perugia, Perugia, Italy. [Van de Mieroop, Els; Nelen, Vera] Prov Inst Hyg, Environm & Hlth Unit, Antwerp, Belgium. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium.-
local.publisher.placeLONDON-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.3109/1354750X.2014.937362-
dc.identifier.isi000340768500007-
item.fulltextNo Fulltext-
item.contributorDe Prins, Sofie-
item.contributorMarcucci, Francesco-
item.contributorSensi, Laura-
item.contributorVan de Mieroop, Els-
item.contributorNelen, Vera-
item.contributorNAWROT, Tim-
item.contributorSchoeters, Greet-
item.contributorKoppen, Gudrun-
item.accessRightsClosed Access-
item.fullcitationDe Prins, Sofie; Marcucci, Francesco; Sensi, Laura; Van de Mieroop, Els; Nelen, Vera; NAWROT, Tim; Schoeters, Greet & Koppen, Gudrun (2014) Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children. In: BIOMARKERS, 19 (6), p. 481-487.-
item.validationecoom 2015-
crisitem.journal.issn1354-750X-
crisitem.journal.eissn1366-5804-
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