Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17832
Title: Airway oxidative stress and inflammation markers in exhaled breath from children are linked with exposure to black carbon.
Authors: De Prins, S.
DONS, Evi 
Van Poppel, M.
INT PANIS, Luc 
Van de Mieroop, E.
Nelen, V.
Cox, Bianca 
NAWROT, Tim 
Teughels, C.
Schoeters, G.
Koppen, G.
Issue Date: 2014
Source: ENVIRONMENT INTERNATIONAL, 73, p. 440-446
Abstract: Background The current study aimed at assessing the associations between black carbon (BC) exposure and markers for airway inflammation and oxidative stress in primary school children in a Western European urban area. Methods In 130 children aged 6–12 years old, the fraction of exhaled nitric oxide (FeNO), exhaled breath condensate (EBC) pH, 8-isoprostane and interleukin (IL)-1β were measured in two seasons. BC concentrations on the sampling day (2-h average, 8:00–10:00 AM) and on the day before (24-h average) were assessed using measurements at a central monitoring site. Land use regression (LUR) models were applied to estimate weekly average BC exposure integrated for the time spent at home and at school, and seasonal average BC exposure at the home address. Associations between exposure and biomarkers were tested using linear mixed effect regression models. Next to single exposure models, models combining different BC exposure metrics were used. Results In single exposure models, an interquartile range (IQR) increase in 2-h BC (3.10 μg/m3) was linked with a 5.9% (95% CI: 0.1 to 12.0%) increase in 8-isoprostane. FeNO increased by 16.7% (95% CI: 2.2 to 33.2%) per IQR increase in 24-h average BC (4.50 μg/m3) and by 12.1% (95% CI: 2.5 to 22.8%) per IQR increase in weekly BC (1.73 μg/m3). IL-1β was associated with weekly and seasonal (IQR = 1.70 μg/m3) BC with respective changes of 38.4% (95% CI: 9.0 to 75.4%) and 61.8% (95% CI: 3.5 to 153.9%) per IQR increase in BC. An IQR increase in weekly BC was linked with a lowering in EBC pH of 0.05 (95% CI: − 0.10 to − 0.01). All associations were observed independent of sex, age, allergy status, parental education level and meteorological conditions on the sampling day. Most of the associations remained when different BC exposure metrics were combined in multiple exposure models, after additional correction for sampling period or after exclusion of children with airway allergies. In additional analyses, FeNO was linked with 24-h PM10 levels, but the effect size was smaller than for BC. 8-Isoprostane was not linked with either 2-h or 24-h concentrations of PM2.5 or PM10. Conclusion BC exposure on the morning of sampling was associated with airway oxidative stress while 24-h and weekly exposures were linked with airway inflammation.
Notes: Koppen, G (reprint author), VITO Flemish Inst Technol Res, Boeretang 200, B-2400 Mol, Belgium. sofie.deprins@vito.be; evi.dons@vito.be; martine.vanpoppel@vito.be; luc.intpanis@vito.be; els.vandemieroop@pih.provant.be; vera.nelen@pih.provant.be; bianca.cox@uhasselt.be; tiranawrot@uhasselt.be; caroline.teughels@lne.vlaanderen.be; greetschoeters@vito.be; gudrun.koppen@vito.be
Keywords: air pollution; land use regression; children; airway inflammation; exhaled breath condensate; biomarkers
Document URI: http://hdl.handle.net/1942/17832
Link to publication: http://www.ncbi.nlm.nih.gov/pubmed/25244707
ISSN: 0160-4120
e-ISSN: 1873-6750
DOI: 10.1016/j.envint.2014.06.017
ISI #: 000345540700049
Rights: © 2014 Elsevier Ltd. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
1-s2.0-S0160412014002013-main.pdfpublished version376.63 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

41
checked on Sep 2, 2020

WEB OF SCIENCETM
Citations

54
checked on May 14, 2022

Page view(s)

142
checked on May 16, 2022

Download(s)

214
checked on May 16, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.