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Title: Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds
Authors: Moore, Laura
Grobarova, Valeria
Shen, Helen
Man, Han Bin
Micova, Julia
Ledvina, Miroslav
Stursa, Jan
Fiserova, Anna
Ho, Dean
Issue Date: 2014
Source: NANOSCALE, 6 (20), p. 11712-11721
Abstract: Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and nanoscale sensing. Although initial studies indicate that these small gems are biocompatible, there is a great deal of variability in synthesis methods and surface functionalization that has yet to be evaluated. Here we present a comprehensive analysis of the cellular compatibility of an array of nanodiamond subtypes and surface functionalization strategies. These results demonstrate that NDs are well tolerated by multiple cell types at both functional and gene expression levels. In addition, ND-mediated delivery of daunorubicin is less toxic to multiple cell types than treatment with daunorubicin alone, thus demonstrating the ability of the ND agent to improve drug tolerance and decrease therapeutic toxicity. Overall, the results here indicate that ND biocompatibility serves as a promising foundation for continued preclinical investigation.
Notes: [Moore, Laura; Shen, Helen; Man, Han Bin] Northwestern Univ, Evanston, IL USA. [Grobarova, Valeria; Fiserova, Anna] Acad Sci Czech Republic, Inst Microbiol, Prague, Czech Republic. [Micova, Julia; Ledvina, Miroslav] Acad Sci Czech Republic, Inst Organ Chem & Biochem, Vvi, Prague, Czech Republic. [Micova, Julia; Ledvina, Miroslav; Nesladek, Milos; Fiserova, Anna] Czech Tech Univ, Fac Biomed Engn, Kladno, Czech Republic. [Stursa, Jan] Acad Sci Czech Republic, Inst Nucl Phys, CZ-25068 Rez, Czech Republic. [Nesladek, Milos] Hasselt Univ, Inst Mat Res IMO, Hasselt, Belgium. [Ho, Dean] Univ Calif Los Angeles, Sch Dent, Jane & Jerry Weintraub Ctr Reconstruct Biotechnol, Div Oral Biol & Med,Div Adv Prosthodont, Los Angeles, CA 90024 USA. [Ho, Dean] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Dept Bioengn, Calif NanoSyst Inst, Los Angeles, CA 90024 USA.
Keywords: Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
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ISSN: 2040-3364
e-ISSN: 2040-3372
DOI: 10.1039/c4nr02570a
ISI #: 000343000800018
Rights: This journal is © The Royal Society of Chemistry 2014.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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