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Title: Changes in physical activity and all-cause mortality in COPD.
Authors: Vaes, Anouk W.
Garcia-Aymerich, Judith
Marott, Jacob L.
Benet, Martha
Groenen, Miriam T.J.
Schnohr, Peter
Franssen, Frits M.E.
Vestbo, Jorgen
Wouters, Emiel F.M.
Lange, Peter
SPRUIT, Martijn A. 
Issue Date: 2014
Source: EUROPEAN RESPIRATORY JOURNAL, 44 (5), p. 1199-1209
Abstract: Little is known about changes in physical activity in subjects with chronic obstructive pulmonary disease (COPD) and its impact on mortality. Therefore, we aimed to study changes in physical activity in subjects with and without COPD and the impact of physical activity on mortality risk. Subjects from the Copenhagen City Heart Study with at least two consecutive examinations were selected. Each examination included a self-administered questionnaire and clinical examination. 1270 COPD subjects and 8734 subjects without COPD (forced expiratory volume in 1 s 67±18 and 91±15% predicted, respectively) were included. COPD subjects with moderate or high baseline physical activity who reported low physical activity level at follow-up had the highest hazard ratios of mortality (1.73 and 2.35, respectively; both p<0.001). In COPD subjects with low baseline physical activity, no differences were found in survival between unchanged or increased physical activity at follow-up. In addition, subjects without COPD with low physical activity at follow-up had the highest hazard ratio of mortality, irrespective of baseline physical activity level (p≤0.05). A decline to low physical activity at follow-up was associated with an increased mortality risk in subjects with and without COPD. These observational data suggest that it is important to assess and encourage physical activity in the earliest stages of COPD in order to maintain a physical activity level that is as high as possible, as this is associated with better prognosis.
Notes: Anouk W. Vaes, CIRO+, Program Development Centre, Hornerheide 1, 6085 NM Horn, The Netherlands. E-mail:
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ISSN: 0903-1936
e-ISSN: 1399-3003
DOI: 10.1183/09031936.00023214
ISI #: 000344909100017
Rights: © ERS 2014.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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