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|Title:||Increased fracture risk in patients with type 2 diabetes mellitus: An overview of the underlying mechanisms and the usefulness of imaging modalities and fracture risk assessment tools||Authors:||de Waard, Ellis A. C.
van Geel, Tineke A. C. M.
VAN DEN BERGH, Joop
|Issue Date:||2014||Publisher:||ELSEVIER IRELAND LTD||Source:||MATURITAS, 79 (3), p. 265-274||Abstract:||Type 2 diabetes mellitus has recently been linked to an increased fracture risk. Since bone mass seems to be normal to elevated in patient with type 2 diabetes, the increased fracture risk is thought to be due to both an increased falling frequency and decreased bone quality. The increased falling frequency is mainly a result of complications of the disease such as a retinopathy and polyneuropathy. Bone quality is affected through changes in bone shape, bone micro-architecture, and in material properties such as bone mineralization and the quality of collagen. Commonly used methods for predicting fracture risk such as dual energy X-ray absorptiometry and fracture risk assessment tools are helpful in patients with type 2 diabetes mellitus, but underestimate the absolute fracture risk for a given score. New imaging modalities such as high resolution peripheral quantitative computed tomography are promising for giving insight in the complex etiology underlying the fragility of the diabetic bone, as they can give more insight into the microarchitecture and geometry of the bone. We present an overview of the contributing mechanisms to the increased fracture risk and the usefulness of imaging modalities and risk assessment tools in predicting fracture risk in patients with type 2 diabetes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.||Notes:||[de Waard, Ellis A. C.; van den Bergh, Joop P. W.] Maastricht Univ Med Ctr NUTRIM, Dept Internal Med, Subdiv Rheumatol, NL-6202 AZ Maastricht, Netherlands. [van Geel, Tineke A. C. M.] Maastricht Univ, CAPHRI, NL-6200 MD Maastricht, Netherlands. [van Geel, Tineke A. C. M.] Maastricht Univ, NUTRIM, Dept Family Med, NL-6200 MD Maastricht, Netherlands. [Savelberg, Hans H. C. M.] Maastricht Univ Med Ctr NUTRIM, Dept Human Movement Sci, NL-6202 AZ Maastricht, Netherlands. [Koster, Annemarie] Maastricht Univ, CAPHRI, Dept Social Med, Sch Publ Hlth & Primary Care, NL-6202 AZ Maastricht, Netherlands. [Geusens, Piet P. M. M.] Maastricht Univ Med Ctr CAPHRI, Dept Internal Med, Subdiv Rheumatol, NL-6202 AZ Maastricht, Netherlands. [Geusens, Piet P. M. M.; van den Bergh, Joop P. W.] Univ Hasselt, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [van den Bergh, Joop P. W.] VieCuri Med Ctr, Dept Internal Med, Subdiv Endocrinol, NL-5900 BX Venlo, Netherlands.||Keywords:||type 2 diabetes mellitus; fractures; bone quality; fall risk; bone mass;Type 2 diabetes mellitus; Fractures; Bone quality; Fall risk; Bone mass||Document URI:||http://hdl.handle.net/1942/18039||ISSN:||0378-5122||e-ISSN:||1873-4111||DOI:||10.1016/j.maturitas.2014.08.003||ISI #:||000344425900006||Rights:||© 2014 Elsevier Ireland Ltd. All rights reserved.||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2015|
|Appears in Collections:||Research publications|
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