Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18046
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dc.contributor.authorHUANG, Yanru-
dc.contributor.authorVan Dessel, Jeroen-
dc.contributor.authorDepypere, Maarten-
dc.contributor.authorEzEldeen, Mostafa-
dc.contributor.authorIliescu, Alexandru Andrei-
dc.contributor.authorDos Santos, Emanuela-
dc.contributor.authorLAMBRICHTS, Ivo-
dc.contributor.authorLIANG, Xin-
dc.contributor.authorJacobs, Reinhilde-
dc.date.accessioned2014-12-19T14:34:52Z-
dc.date.available2014-12-19T14:34:52Z-
dc.date.issued2014-
dc.identifier.citationBONE RESEARCH, 2-
dc.identifier.issn2095-4700-
dc.identifier.urihttp://hdl.handle.net/1942/18046-
dc.description.abstractCone-beam computed tomography (CBCT) has been recently used to analyse trabecular bone structure around dental implants. To validate the use of CBCT for three-dimensional (3D) peri-implant trabecular bone morphometry by comparing it to two-dimensional (2D) histology, 36 alveolar bone samples (with implants n=27 vs. without implants n=9) from six mongrel dogs, were scanned ex vivo using a high-resolution (80 mu m) CBCT. After scanning, all samples were decalcified and then sectioned into thin histological sections (similar to 6 mu m) to obtain high contrast 2D images. By using CT An imaging software, bone morphometric parameters including trabecular number (Tb.N), thickness (Tb.Th), separation (Tb.Sp) and bone volume fraction (BV/TV) were examined on both CBCT and corresponding histological images. Higher Tb. Th and Tb. Sp, lower BV/TV and Tb.N were found on CBCT images (P<0.001). Both measurements on the peri-implant trabecular bone structure showed moderate to high correlation (r=0.65-0.85). The Bland-Altman plots showed strongest agreement for Tb.Th followed by Tb.Sp, Tb.N and BV/TV, regardless of the presence of implants. The current findings support the assumption that peri-implant trabecular bone structures based on high-resolution CBCT measurements are representative for the underlying histological bone characteristics, indicating a potential clinical diagnostic use of CBCT-based peri-implant bone morphometric characterisation.-
dc.description.sponsorshipWe are grateful to Jeanine Santermans and Marc Jans for their technical assistance. The study was supported by grants from the Interfaculty Council for Development Co-operation (IRO), KU Leuven, Belgium. The authors declare no potential conflicts of interest in this study.-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.rights© 2014 Sichuan University All rights reserved 2095-4700/14-
dc.titleValidating cone-beam computed tomography for peri-implant bone morphometric analysis-
dc.typeJournal Contribution-
dc.identifier.volume2-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notes[Huang, Yan; Van Dessel, Jeroen; EzEldeen, Mostafa; Jacobs, Reinhilde] Univ Leuven, Fac Med, Dept Imaging & Pathol, OMFS IMPATH Res Grp, Leuven, Belgium. [Huang, Yan; Van Dessel, Jeroen; EzEldeen, Mostafa; Jacobs, Reinhilde] Univ Hosp Leuven, Leuven, Belgium. [Huang, Yan] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610064, Peoples R China. [Depypere, Maarten] Katholieke Univ Leuven, ESAT PSI, Leuven, Belgium. [Iliescu, Alexandru Andrei] UMF Craiova, Fac Dent, Craiova, Romania. [Dos Santos, Emanuela] Pontificia Univ Catolica Parana, Sch Dent, Curitiba, Parana, Brazil. [Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. [Liang, Xin] Dalian Med Univ, Sch Stomatol, Dalian, Peoples R China.-
local.publisher.placeLONDON-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1038/boneres.2014.10-
dc.identifier.isi000344998000001-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.contributorJacobs, Reinhilde-
item.contributorEzEldeen, Mostafa-
item.contributorLAMBRICHTS, Ivo-
item.contributorIliescu, Alexandru Andrei-
item.contributorDos Santos, Emanuela-
item.contributorHUANG, Yanru-
item.contributorVan Dessel, Jeroen-
item.contributorLIANG, Xin-
item.contributorDepypere, Maarten-
item.fullcitationHUANG, Yanru; Van Dessel, Jeroen; Depypere, Maarten; EzEldeen, Mostafa; Iliescu, Alexandru Andrei; Dos Santos, Emanuela; LAMBRICHTS, Ivo; LIANG, Xin & Jacobs, Reinhilde (2014) Validating cone-beam computed tomography for peri-implant bone morphometric analysis. In: BONE RESEARCH, 2.-
item.validationecoom 2015-
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