Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18109
Title: Sperm functional tests
Authors: Oehninger, Sergio
Franken, Daniel R.
OMBELET, Willem 
Issue Date: 2014
Publisher: ELSEVIER SCIENCE INC
Source: FERTILITY AND STERILITY, 102 (6), p. 1528-1533
Abstract: Several semen parameters are used to discriminate the fertile male from the subfertile male. The most widely used parameters are sperm concentration, motility, progressive motility, and sperm morphology. Semen analysis is usually applied as described in the World Health Organization manual for semen analysis. In addition to a routine semen analysis, sperm functional tests have been described for many years, which in most cases are regarded as research tools and not part of the routine semen testing in an infertility clinic. In this review we report on the value of four sperm function tests: the sperm penetration assay, the sperm- zona pellucida binding tests, the acrosome reaction, and the hyaluronan binding assay. For each test we describe the current value, the indication for performing the test, how to interpret the results, and its therapeutic implications. Our data show that sperm functional assays are highly predictive of IVF outcome results and have the potential to assist in clinical decision making, especially to avoid the current long- standing treatment with IUI and to direct the patients to intracytoplasmic sperm injection without delay when sperm functional testing fails. We believe that advances in molecular biology techniques will allow us to develop simpler sperm function assays in the near future. This will undoubtedly help clinicians in optimizing male factor infertility diagnosis and treatment. (C)2014 by American Society for Reproductive Medicine.
Notes: [Oehninger, Sergio] Eastern Virginia Med Sch, Jones Inst Reprod Med, Dept Obstet & Gynaecol, Norfolk, VA 23501 USA. [Franken, Daniel R.] Univ Free State, Dept Obstet & Gynecol, Bloemfontein, South Africa. [Ombelet, Willem] ZOL Hosp, Genk Inst Fertil Technol, B-3600 Genk, Belgium. [Ombelet, Willem] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium.
Keywords: Acrosome reaction; male infertility; sperm functional test; sperm penetration assay; sperm-zona pellucida binding tests
Document URI: http://hdl.handle.net/1942/18109
ISSN: 0015-0282
e-ISSN: 1556-5653
DOI: 10.1016/j.fertnstert.2014.09.044
ISI #: 000345613600005
Category: A1
Type: Journal Contribution
Validations: ecoom 2016
Appears in Collections:Research publications

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