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|Title:||Possible morphological substrates in the pathogenesis of arthritis||Authors:||VAN ZWIETEN, Koos Jaap
de Bakker, Bernadette S.
De Munter, Stephanie
|Issue Date:||2015||Publisher:||Nederlandse Anatomen Vereniging - Dutch Anatomical Society||Source:||Dr. M. Spinder, Secretary of the Dutch Anatomical Society (Ed.). Proceedings, Program and Book of Abstracts of the Dutch Anatomical Society, 177th Scientific Meeting, p. 16-16||Abstract:||To gain more insight into the morphogenesis of synovial joints, as well as into pathogeneses of joint diseases like Rheumatoid Arthritis (RA) and possibly also Osteoarthritis (OA), we surveyed human finger joint ontogeny from early developmental stages. In adult interphalangeal joints, dorsal and palmar but also ulnar and radial synovial folds do persist. During adult life, synovial membranes as well as synovial folds (e.g., after micro-damage) may elicit chronic inflammatory processes that eventually lead to arthritis. In proximal interphalangeal (PIP) joint proper collateral ligaments (PCL), we found neurofilaments and oval-shaped lamellated corpuscles (ø ≈ 120 µ). Supposedly acting as mechanoreceptors, these may also produce cytokines and substance P, a neuropeptide involved in pain. As the PIP-joints of fingers in particular show symptoms of Rheumatoid Arthritis at early stages, these organs may therefore play a role in the pathogenesis of arthritis.||Notes:||Acknowledgements: The authors thank Mrs. Jeanine Santermans, BioMed Research Centre, University of Hasselt, for her invaluable technical support during this study. Andrej Bezmaternykh and Youssef El Jerrari, BSc Students of Biomedical Sciences at the University of Hasselt, and Yasmina Azdud, Sebastiaan Deckers, Emiel Ectors, Erwin Leysen and Shamaila Naeem, MSc Students of Biomedical Sciences at the University of Hasselt, are thanked for their keen interest during the project.||Keywords:||synovial joints; interphalangeal joints; Proper Collateral Ligaments (PCL); morphogenesis; synovial folds; molecular mechanisms; histology; neurofilaments; lamellated corpuscules; pathogenesis of Rheumatoid Arthritis (RA) and Osteoarthritis (OA)||Document URI:||http://hdl.handle.net/1942/18111||Link to publication:||https://www.researchgate.net/publication/270648262_Possible_morphological_substrates_in_the_pathogenesis_of_arthritis||DOI:||10.13140/2.1.3712.2886||Rights:||© 2015 Nederlandse Anatomen Vereniging - © 2015 Dutch Anatomical Society||Category:||C2||Type:||Proceedings Paper|
|Appears in Collections:||Research publications|
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