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http://hdl.handle.net/1942/18135
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DC Field | Value | Language |
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dc.contributor.author | WENS, Inez | - |
dc.contributor.author | Dalgas, Ulrik | - |
dc.contributor.author | VANDENABEELE, Frank | - |
dc.contributor.author | Krekels, Maartje | - |
dc.contributor.author | Grevendonk, Lotte | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.date.accessioned | 2015-01-19T13:41:18Z | - |
dc.date.available | 2015-01-19T13:41:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | PLOS ONE, 9 (9) | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18135 | - |
dc.description.abstract | Background: The impact of multiple sclerosis (MS) on skeletal muscle characteristics, such as muscle fiber cross sectional area (CSA), fiber type proportion, muscle strength and whole muscle mass, remains conflicting. Methods: In this cross sectional study, body composition and muscle strength of the quadriceps were assessed in 34 MS (EDSS: 2.560.19) patients and 18 matched healthy controls (HC). Hereafter a muscle biopsy (m.vastus lateralis) was taken. Results: Compared to HC, mean muscle fiber CSA of all fibers, as well as CSA of type I, II and IIa fibers were smaller and muscle strength of the quadriceps was lower in MS patients. Whole body composition was comparable between groups. However, compared to HC, the biopsied leg tended to have a higher fat percentage (p = 0.1) and a lower lean mass (p = 0.06) in MS patients. Conclusion: MS seems to negatively influence skeletal muscle fiber CSA, muscle strength and muscle mass of the lower limbs of mildly affected MS patients. This emphasises the need for rehabilitation programs focusing on muscle preservation of the lower limb. Trial Registration: ClinicalTrials.gov NCT01845896 | - |
dc.description.sponsorship | Inez Wens and Bert Op't Eijnde received support from MS Fund Limburg, Flanders. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.rights | Copyright: © 2014 Wens et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.title | Multiple Sclerosis Affects Skeletal Muscle Characteristics | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 9 | - |
dc.identifier.volume | 9 | - |
local.format.pages | 5 | - |
local.format.pages | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Wens, Inez; Vandenabeele, Frank; Krekels, Maartje; Grevendonk, Lotte; Eijnde, Bert O.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Hasselt, Belgium. [Dalgas, Ulrik] Aarhus Univ, Dept Publ Hlth, Sect Sport Sci, Aarhus C, Denmark. | - |
local.publisher.place | SAN FRANCISCO | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0108158 | - |
dc.identifier.isi | 000345745400045 | - |
item.validation | ecoom 2016 | - |
item.accessRights | Open Access | - |
item.fullcitation | WENS, Inez; Dalgas, Ulrik; VANDENABEELE, Frank; Krekels, Maartje; Grevendonk, Lotte & OP 'T EIJNDE, Bert (2014) Multiple Sclerosis Affects Skeletal Muscle Characteristics. In: PLOS ONE, 9 (9). | - |
item.fulltext | With Fulltext | - |
item.contributor | WENS, Inez | - |
item.contributor | Dalgas, Ulrik | - |
item.contributor | VANDENABEELE, Frank | - |
item.contributor | Krekels, Maartje | - |
item.contributor | Grevendonk, Lotte | - |
item.contributor | OP 'T EIJNDE, Bert | - |
crisitem.journal.issn | 1932-6203 | - |
crisitem.journal.eissn | 1932-6203 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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wens 1.pdf | Published version | 458.35 kB | Adobe PDF | View/Open |
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