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http://hdl.handle.net/1942/18177
Title: | Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution - A critical review | Authors: | Bai, Yang Brugha, Rossa E. Jacobs, Lotte Grigg, Jonathan NAWROT, Tim Nemery, Benoit |
Issue Date: | 2015 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Source: | ENVIRONMENT INTERNATIONAL, 74, p. 32-41 | Abstract: | Exposure to particulate matter (PM) is associated with adverse health effects, including chronic lung diseases, lung cancer and cardiovascular disease. Personal exposure varies depending on the generation of particles locally, background levels, activity patterns and meteorology. Carbon loading in airway macrophages (AM) is a novel marker to assess personal exposure to combustion-derived particles. This review summarizes the published evidence and describes the validity and reliability of this marker with a focus on the technical aspects. Carbon loading in AM is reported in nine published studies assessing personal exposure to particulate air pollution. The carbon content is quantified by image analysis and is suggested to be suited to assess cumulative exposures. While there is some variation in study technique, these studies each indicate that internal AM carbon reflects either external exposure or important health effects. However, some uncertainty remains regarding potentially confounding materials within particles, the time frame of exposures that this technique reflects, and the optimal strategy to accurately quantify AM carbon. These aspects need to be clarified or optimized before applying this technique in larger populations. | Notes: | [Bai, Yang; Jacobs, Lotte; Nawrot, Tim S.; Nemery, Benoit] Katholieke Univ Leuven, Ctr Environm & Hlth, Dept Publ Hlth & Primary Care, B-3000 Louvain, Belgium. [Brugha, Rossa E.; Grigg, Jonathan] Univ London, Barts & London Sch Med & Dent, Ctr Paediat, Blizard Inst, London E1 2AT, England. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. | Keywords: | Carbon loading; Airway macrophages; Particulate matter; Air pollution;carbon loading; airway macrophages; particulate matter; air pollution | Document URI: | http://hdl.handle.net/1942/18177 | ISSN: | 0160-4120 | e-ISSN: | 1873-6750 | DOI: | 10.1016/j.envint.2014.09.010 | ISI #: | 000346681700005 | Rights: | © 2014 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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