Please use this identifier to cite or link to this item:
Title: Blood Pressure in Relation to Environmental Lead Exposure in the National Health and Nutrition Examination Survey 2003 to 2010
Authors: Hara, Azusa
Thijs, Lutgarde
Asayama, Kei
Gu, Yu-Mei
Jacobs, Lotte
Zhang, Zhen-Yu
Liu, Yan-Ping
Staessen, Jan A.
Issue Date: 2015
Source: HYPERTENSION, 65 (1), p. 62-69
Abstract: In view of the declining environmental lead exposure in the United States, we analyzed the National Health and Nutrition Examination Survey (2003-2010) for association of blood pressure and hypertension with blood lead. The 12 725 participants included 21.1% blacks, 20.5% Hispanics, 58.4% whites, and 48.7% women. Blacks compared with non-Blacks had higher systolic and diastolic pressures (126.5 versus 123.9 and 71.9 versus 69.6 mm Hg) and higher hypertension prevalence (44.7 versus 36.8%). Blood lead was lower in whites than in non-whites (1.46 versus 1.57 mu g/dL) and in women than in men (1.25 versus 1.80 mu g/dL). In multivariable analyses of all participants, blood lead doubling was associated with higher (P <= 0.0007) systolic and diastolic pressure (+0.76 mm Hg; 95% confidence interval, 0.38-1.13 and +0.43 mm Hg; 0.18-0.68), but not with the odds of hypertension (0.95; 0.90-1.01; P=0.11). Associations with blood lead were nonsignificant (P >= 0.09) for systolic pressure in women and for diastolic pressure in non-whites. Among men, systolic pressure increased with blood lead (P <= 0.060) with effect sizes associated with blood lead doubling ranging from +0.65 mm Hg in whites to +1.61 mm Hg in blacks. For systolic pressure, interactions of ethnicity and sex with blood lead were all significant (P <= 0.019). In conclusion, small and inconsistent effect sizes in the associations of blood pressure with blood lead likely exclude current environmental lead exposure as a major hypertension cause in the United States.
Notes: [Hara, Azusa; Thijs, Lutgarde; Gu, Yu-Mei; Jacobs, Lotte; Zhang, Zhen-Yu; Liu, Yan-Ping; Staessen, Jan A.] Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, BE-3000 Leuven, Belgium. [Asayama, Kei] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo 173, Japan. [Nawrot, Tim S.] Univ Hasselt, Ctr Environm Sci, Hasselt, Belgium. [Staessen, Jan A.] Maastricht Univ, Res Dev Grp VitaK, Maastricht, Netherlands.
Keywords: blood pressure; environmental medicine; hypertension; lead; toxicology;blood pressure; environmental medicine; hypertension; lead; toxicology
Document URI:
ISSN: 0194-911X
e-ISSN: 1524-4563
DOI: 10.1161/HYPERTENSIONAHA.114.04023
ISI #: 000346248800017
Rights: © 2014 American Heart Association, Inc.
Category: A1
Type: Journal Contribution
Validations: ecoom 2016
Appears in Collections:Research publications

Show full item record


checked on Sep 2, 2020


checked on May 14, 2022

Page view(s)

checked on May 19, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.