Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/18182
Title: | Blood Pressure in Relation to Environmental Lead Exposure in the National Health and Nutrition Examination Survey 2003 to 2010 | Authors: | Hara, Azusa Thijs, Lutgarde Asayama, Kei Gu, Yu-Mei Jacobs, Lotte Zhang, Zhen-Yu Liu, Yan-Ping NAWROT, Tim Staessen, Jan A. |
Issue Date: | 2015 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | HYPERTENSION, 65 (1), p. 62-69 | Abstract: | In view of the declining environmental lead exposure in the United States, we analyzed the National Health and Nutrition Examination Survey (2003-2010) for association of blood pressure and hypertension with blood lead. The 12 725 participants included 21.1% blacks, 20.5% Hispanics, 58.4% whites, and 48.7% women. Blacks compared with non-Blacks had higher systolic and diastolic pressures (126.5 versus 123.9 and 71.9 versus 69.6 mm Hg) and higher hypertension prevalence (44.7 versus 36.8%). Blood lead was lower in whites than in non-whites (1.46 versus 1.57 mu g/dL) and in women than in men (1.25 versus 1.80 mu g/dL). In multivariable analyses of all participants, blood lead doubling was associated with higher (P <= 0.0007) systolic and diastolic pressure (+0.76 mm Hg; 95% confidence interval, 0.38-1.13 and +0.43 mm Hg; 0.18-0.68), but not with the odds of hypertension (0.95; 0.90-1.01; P=0.11). Associations with blood lead were nonsignificant (P >= 0.09) for systolic pressure in women and for diastolic pressure in non-whites. Among men, systolic pressure increased with blood lead (P <= 0.060) with effect sizes associated with blood lead doubling ranging from +0.65 mm Hg in whites to +1.61 mm Hg in blacks. For systolic pressure, interactions of ethnicity and sex with blood lead were all significant (P <= 0.019). In conclusion, small and inconsistent effect sizes in the associations of blood pressure with blood lead likely exclude current environmental lead exposure as a major hypertension cause in the United States. | Notes: | [Hara, Azusa; Thijs, Lutgarde; Gu, Yu-Mei; Jacobs, Lotte; Zhang, Zhen-Yu; Liu, Yan-Ping; Staessen, Jan A.] Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, BE-3000 Leuven, Belgium. [Asayama, Kei] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo 173, Japan. [Nawrot, Tim S.] Univ Hasselt, Ctr Environm Sci, Hasselt, Belgium. [Staessen, Jan A.] Maastricht Univ, Res Dev Grp VitaK, Maastricht, Netherlands. | Keywords: | blood pressure; environmental medicine; hypertension; lead; toxicology;blood pressure; environmental medicine; hypertension; lead; toxicology | Document URI: | http://hdl.handle.net/1942/18182 | ISSN: | 0194-911X | e-ISSN: | 1524-4563 | DOI: | 10.1161/HYPERTENSIONAHA.114.04023 | ISI #: | 000346248800017 | Rights: | © 2014 American Heart Association, Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
Show full item record
SCOPUSTM
Citations
32
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
57
checked on Apr 22, 2024
Page view(s)
28
checked on Sep 5, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.