Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/18205
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Serbruyns, Leen | - |
dc.contributor.author | Leunissen, Inge | - |
dc.contributor.author | Huysmans, Toon | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.contributor.author | MEESEN, Raf | - |
dc.contributor.author | Van Ruitenbeek, Peter | - |
dc.contributor.author | Sijbers, Jan | - |
dc.contributor.author | Swinnen, Stephan | - |
dc.date.accessioned | 2015-02-02T08:21:50Z | - |
dc.date.available | 2015-02-02T08:21:50Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | CORTEX. 65, p. 128-138 | - |
dc.identifier.issn | 0010-9452 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18205 | - |
dc.description.abstract | Even though declines in sensorimotor performance during healthy aging have been documented extensively, its underlying neural mechanisms remain unclear. Here, we explored whether age-related subcortical atrophy plays a role in sensorimotor performance declines, and particularly during bimanual manipulative performance (Purdue Pegboard Test). The thalamus, putamen, caudate and pallidum of 91 participants across the adult lifespan (ages 20 – 79 years) were automatically segmented. In addition to studying age-related changes in the global volume of each subcortical structure, local deformations within these structures, indicative of subregional volume changes, were assessed by means of recently developed shape analyses. Results showed widespread age-related global and subregional atrophy, as well as some notable subregional expansion. Even though global atrophy failed to explain the observed performance declines with aging, shape analyses indicated that atrophy in left and right thalamic subregions, specifically subserving connectivity with the premotor, primary motor and somatosensory cortical areas, mediated the relation between aging and performance decline. It is concluded that subregional volume assessment by means of shape analyses offers a sensitive tool with high anatomical resolution in the search for specific age-related associations between brain structure and behavior. | - |
dc.description.sponsorship | This work was supported by grants from the Research Fund of KU Leuven, Belgium (OT/11/071), the Flanders Fund for Scientific Research (G0721.12, G0708.14) and Grant P7/11 from the Inter-university Attraction Poles program of the Belgian Federal Government. I. Leunissen is funded by a postdoctoral fellowship of the Research Foundation - Flanders (FWO). | - |
dc.language.iso | en | - |
dc.subject.other | aging; coordination; thalamus; shape; mediation | - |
dc.title | Subcortical volumetric changes across the adult lifespan: subregional thalamic atrophy accounts for age-related sensorimotor performance declines | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 138 | - |
dc.identifier.spage | 128 | - |
dc.identifier.volume | 65 | - |
local.format.pages | 37 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Swinnen, SP (reprint author), Katholieke Univ Leuven, Dept Kinesiol, Movement Control & Neuroplast Res Grp, Motor Control Lab,Biomed Sci Grp, Tervuursevest 101, B-3001 Heverlee, Belgium. Stephan.Swinnen@faber.kuleuven.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.cortex.2015.01.003 | - |
dc.identifier.isi | 000353739300011 | - |
item.fullcitation | Serbruyns, Leen; Leunissen, Inge; Huysmans, Toon; CUYPERS, Koen; MEESEN, Raf; Van Ruitenbeek, Peter; Sijbers, Jan & Swinnen, Stephan (2015) Subcortical volumetric changes across the adult lifespan: subregional thalamic atrophy accounts for age-related sensorimotor performance declines. In: CORTEX. 65, p. 128-138. | - |
item.validation | ecoom 2016 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | Serbruyns, Leen | - |
item.contributor | Leunissen, Inge | - |
item.contributor | Huysmans, Toon | - |
item.contributor | CUYPERS, Koen | - |
item.contributor | MEESEN, Raf | - |
item.contributor | Van Ruitenbeek, Peter | - |
item.contributor | Sijbers, Jan | - |
item.contributor | Swinnen, Stephan | - |
crisitem.journal.issn | 0010-9452 | - |
crisitem.journal.eissn | 1973-8102 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
article (2).pdf | 714.49 kB | Adobe PDF | View/Open | |
serbruyns 1.pdf Restricted Access | Published version | 1.31 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
21
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
32
checked on May 16, 2024
Page view(s)
156
checked on Sep 7, 2022
Download(s)
348
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.