Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/18209
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | VANHEUSDEN, Marjan | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | 't HART, Bert A. | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.date.accessioned | 2015-02-02T09:46:28Z | - |
dc.date.available | 2015-02-02T09:46:28Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | TRENDS IN MOLECULAR MEDICINE, 21 (1), p. 16-23 | - |
dc.identifier.issn | 1471-4914 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18209 | - |
dc.description.abstract | Multiple sclerosis (MS) is a chronic disabling autoimmune disease of the central nervous system (CNS). Cytomegalovirus (CMV), a β herpes virus, may have a detrimental or beneficial role in MS pathology. Accumulating evidence indicates that CMV contributes to MS disease via interplay of different mechanisms such as molecular mimicry, bystander activation, and epitope spreading. The activation and expansion of a specific T cell subset, CD4+CD28null T cells, via CMV infection could also contribute to MS pathology. Various additional observations also indicate a protective effect of CMV on autoimmune diseases. CMV immune evasion may mitigate the autoimmune reactions and proinflammatory milieu that contribute to MS. | - |
dc.language.iso | en | - |
dc.rights | Copyright © 2014 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | cytomegalovirus; multiple sclerosis | - |
dc.title | Cytomegalovirus: a culprit or protector in multiple sclerosis? | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 23 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 16 | - |
dc.identifier.volume | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Corresponding author: Hellings, N. (niels.hellings@uhasselt.be). | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/j.molmed.2014.11.002 | - |
dc.identifier.isi | 000347862800003 | - |
item.contributor | VANHEUSDEN, Marjan | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | 't HART, Bert A. | - |
item.contributor | HELLINGS, Niels | - |
item.validation | ecoom 2016 | - |
item.fullcitation | VANHEUSDEN, Marjan; STINISSEN, Piet; 't HART, Bert A. & HELLINGS, Niels (2015) Cytomegalovirus: a culprit or protector in multiple sclerosis?. In: TRENDS IN MOLECULAR MEDICINE, 21 (1), p. 16-23. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1471-4914 | - |
crisitem.journal.eissn | 1471-499X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S1471491414001944-main.pdf Restricted Access | 986.58 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
24
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
43
checked on Apr 22, 2024
Page view(s)
162
checked on Apr 26, 2023
Download(s)
136
checked on Apr 26, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.