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http://hdl.handle.net/1942/18300
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DC Field | Value | Language |
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dc.contributor.author | HOSSEINKHANI, Baharak | - |
dc.contributor.author | Callewaert, Chris | - |
dc.contributor.author | Vanbeveren, Nelleke | - |
dc.contributor.author | Boon, Nico | - |
dc.date.accessioned | 2015-02-09T11:36:10Z | - |
dc.date.available | 2015-02-09T11:36:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | NEW BIOTECHNOLOGY, 32 (1), p. 40-46 | - |
dc.identifier.issn | 1871-6784 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18300 | - |
dc.description.abstract | There is a growing demand for fragranced products, but due to the poor aqueous solubility and instability of fragrance molecules, their use is limited. Nowadays, fragrance encapsulation in biocompatible nanocontainer material is emerging as a novel strategy to overcome the evaporation of volatile molecules and to prolong the sensory characteristics of fragrance molecules and the longevity of perfumes. The objective of this study was to develop an innovative sustained release system of perfume, by entrapping fragrance molecules in a polymeric nanocarrier; the impact of this strategy on the human axillary microbiome was further assessed. Stabilised poly-L-lactic acid nanocapsules (PLA-NCs) with a diameter of approximately 115 nm were prepared through nanoprecipitation. Size and morphology of the capsules were evaluated using Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS). Two model hydrophobic compounds, chlorobenzene and fluorescein, representing two different types of functionalised molecules, were encapsulated in PLA-NCs with an efficiency rate of 50%. Different release behaviours were seen, dependent on hydrophobicity. For hydrophobic compounds, a steady release was observed over 48 hours. The polymeric nanocarriers did not impact the human axillary microbiome. Because of the slow and sustained release of fragrances, encapsulation of molecules in biocompatible NCs can represent a revolutionary contribution to the future of toiletries, body deodorant products, and in washing and cleaning sectors. | - |
dc.description.sponsorship | BH was supported by the project grant from the EU Commission within the 7th Framework Programme (FP7-KBBE-2010-4) and EU ULIXES project (266473). The research was funded by the Flemish Government and Ghent University through the assistantship of CC. BH, CC and NB designed the experiments. NV, BH and CC performed the experiments and analysed the data. BH and CC wrote the paper. NB commented on the manuscript. We thank Tom Van de Wiele, Emma Hernandez Sanabria and Jianyun Wang for their critical review of the manuscript and the inspiring discussions. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2014 Elsevier B.V. All rights reserved. | - |
dc.title | Novel biocompatible nanocapsules for slow release of fragrances on the human skin | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 46 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 40 | - |
dc.identifier.volume | 32 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Hosseinkhani, Baharak; Callewaert, Chris; Vanbeveren, Nelleke; Boon, Nico] Univ Ghent, Lab Microbial Ecol & Technol LabMET, B-9000 Ghent, Belgium. [Hosseinkhani, Baharak] Univ Hasselt, BIOMED, B-3590 Diepenbeek, Belgium. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.nbt.2014.09.001 | - |
dc.identifier.isi | 000347507800007 | - |
item.contributor | HOSSEINKHANI, Baharak | - |
item.contributor | Callewaert, Chris | - |
item.contributor | Vanbeveren, Nelleke | - |
item.contributor | Boon, Nico | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2016 | - |
item.fullcitation | HOSSEINKHANI, Baharak; Callewaert, Chris; Vanbeveren, Nelleke & Boon, Nico (2015) Novel biocompatible nanocapsules for slow release of fragrances on the human skin. In: NEW BIOTECHNOLOGY, 32 (1), p. 40-46. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1871-6784 | - |
crisitem.journal.eissn | 1876-4347 | - |
Appears in Collections: | Research publications |
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hosseinkhani 1.pdf Restricted Access | Published version | 723.58 kB | Adobe PDF | View/Open Request a copy |
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