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http://hdl.handle.net/1942/18352
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DC Field | Value | Language |
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dc.contributor.author | Heremans, L. | - |
dc.contributor.author | PENNEMANS, Valerie | - |
dc.contributor.author | SWENNEN, Quirine | - |
dc.contributor.author | PENDERS, Joris | - |
dc.contributor.author | Dubois, J. | - |
dc.contributor.author | VANDER LAENEN, Margot | - |
dc.contributor.author | BOER, Willem | - |
dc.date.accessioned | 2015-02-24T15:35:58Z | - |
dc.date.available | 2015-02-24T15:35:58Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Abstract Book 5th Networking World Anesthesia Convention (NWAC), p. 12-12 | - |
dc.identifier.issn | 0026-4806 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18352 | - |
dc.description.abstract | Aims. AKI is common after cardiac surgery involving CPB. S-cystatin C is a novel early biomarker for AKI awaiting validation in this setting. Goal was to develop a clinical predictive model for AKI and test the added value of s-cystatin C within the first 24 hrs post-op. Methods. 259 patients were enrolled. Patients with severe pre-existing renal insufficiency were excluded (eGFR<15 ml/min). Urine and blood samples were obtained immediately before initiation of CPB, at 3h, 6h, 12h and 24h post-op. Patients were retrospectively divided into 2 groups, AKI (n=84)(32%) and non-AKI (n=175)(68%), based on the AKIN criteria (increase in s-Creat ≥ 0.3 mg/dl or ≥ 50% compared to baseline within 48h or reduction in Urine output <0.5 ml/kg/h for more than 6h). Statistical analysis to determine which clinical factors were predictive for AKI was performed (diabetes was not included). Subsequent analysis of the added value of serum-cystatin C to this model. Results. Only duration of CPB, BMI and pre-op eGFR had predictive value in the clinical setting with the following combined AUC scores for AKI: 0.737 (3h post-op), 0.767 (6h post-op), 0.745 (12h post-op) and 0.755 (24h post-op). Addition of s-cystatin C increased the discriminative power at time points preop, 3h post-op, 6h post-op and 12h post-op (AUC scores of 0.776, 0.823 and 0.798 resp, all p<0.05 compared to clinical model alone). Conclusion. Addition of s-cystatin C to a predictive clinical model for AKI has significant added value. | - |
dc.language.iso | en | - |
dc.relation.ispartofseries | Minerva Medica | - |
dc.subject.other | acute kidney injury; cardio pulmonary bypass; serum cystatine; pre-ICU | - |
dc.title | Added value of serum-cystatin C in cardiac surgery patients with cpb developing AKI | - |
dc.type | Proceedings Paper | - |
local.bibliographicCitation.conferencedate | 30 april - 3 may 2014 | - |
local.bibliographicCitation.conferencename | 5th Networking World Anesthesia Convention (NWAC) | - |
local.bibliographicCitation.conferenceplace | Vienna, Austria | - |
dc.identifier.epage | 12 | - |
dc.identifier.spage | 12 | - |
local.bibliographicCitation.jcat | C1 | - |
local.publisher.place | Torino, Italy | - |
local.type.refereed | Refereed | - |
local.type.specified | Abstract | - |
local.relation.ispartofseriesnr | 105 | - |
local.bibliographicCitation.btitle | Abstract Book 5th Networking World Anesthesia Convention (NWAC) | - |
item.contributor | Heremans, L. | - |
item.contributor | PENNEMANS, Valerie | - |
item.contributor | SWENNEN, Quirine | - |
item.contributor | PENDERS, Joris | - |
item.contributor | Dubois, J. | - |
item.contributor | VANDER LAENEN, Margot | - |
item.contributor | BOER, Willem | - |
item.accessRights | Open Access | - |
item.fullcitation | Heremans, L.; PENNEMANS, Valerie; SWENNEN, Quirine; PENDERS, Joris; Dubois, J.; VANDER LAENEN, Margot & BOER, Willem (2014) Added value of serum-cystatin C in cardiac surgery patients with cpb developing AKI. In: Abstract Book 5th Networking World Anesthesia Convention (NWAC), p. 12-12. | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Online-Abstract-Book.13.pdf | 55.02 kB | Adobe PDF | View/Open |
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