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http://hdl.handle.net/1942/18353
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DC Field | Value | Language |
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dc.contributor.author | Mertens, Karolien | - |
dc.contributor.author | PENNEMANS, Valerie | - |
dc.contributor.author | PENDERS, Joris | - |
dc.contributor.author | SWENNEN, Quirine | - |
dc.contributor.author | VANDER LAENEN, Margot | - |
dc.contributor.author | VANELDEREN, Pascal | - |
dc.contributor.author | BOER, Willem | - |
dc.date.accessioned | 2015-02-24T16:13:52Z | - |
dc.date.available | 2015-02-24T16:13:52Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Abstract Book 5th Networking World Anesthesia Convention (NWAC), p. 13-13 | - |
dc.identifier.issn | 0026-4806 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18353 | - |
dc.description.abstract | Aims. AKI is common after cardiac surgery involving CPB. Lack of reliable early detection methods for post-op AKI limits timely therapeutic intervention. A number of new biomarkers for AKI await validation in this setting. Analysis of a database was performed to define baseline patient and biomarker characteristics in patients developing AKI. Methods. 259 patients were enrolled. Patients with severe pre-existing renal insufficiency were excluded (eGFR<15ml/min). Urine and blood samples were obtained immediately before initiation of CPB. Patients were retrospectively divided into 2 groups, AKI (n=84) and non-AKI (n=175), based on the AKIN criteria (increase in s-Creat ≥ 0.3 mg/dl or ≥ 50% compared to baseline within 48h or reduction in Urine output <0.5 ml/kg/h for more than 6h). Statistical analysis of all characteristics before arrival on the ICU was performed. Results. AKI patients (32% of total) were older (70 yrs (SD= 9) vs 67 (11), p=0.043) with higher BMI’s (27.7 (4.8) vs. 26.7 (4.3), p=0.036). As to be expected baseline eGFR (CKD-EPI, in ml/min) was lower in the AKI-group (69.49 (20.30) vs. 76.45 (15.01), p=0.024). Both baseline urinary-NGAL (μg/l)(1211 (2172) vs. 749 (946), p=0.020) and serum-cystatin C (in mg/L)(0.98 (0.39) vs 0.86 (0.36), p=0.0175) were statistically higher in the AKI group and CPB time (in minutes) was significantly longer: 163 (63) vs 121 (51), p<0.0001. Conclusion. u-NGAL and s-Cystatin most likely reflect pre-existing kidney dysfunction (like eGFR). CPB time is a significant factor for development of AKI, which is amenable to improvement. | - |
dc.language.iso | en | - |
dc.relation.ispartofseries | Minerva Medica | - |
dc.subject.other | acute kidney injury; cardio pulmonary bypass; pre-ICU | - |
dc.title | Pre-ICU characteristics in cardiac surgery patients with CPB developing AKI | - |
dc.type | Proceedings Paper | - |
local.bibliographicCitation.conferencedate | 30 april - 3 may 2014 | - |
local.bibliographicCitation.conferencename | 5th Networking World Anesthesia Congress (NWAC) | - |
local.bibliographicCitation.conferenceplace | Vienna, Austria | - |
dc.identifier.epage | 13 | - |
dc.identifier.spage | 13 | - |
local.bibliographicCitation.jcat | C1 | - |
local.publisher.place | Torino, Italy | - |
local.type.refereed | Refereed | - |
local.type.specified | Abstract | - |
local.relation.ispartofseriesnr | 105 | - |
local.bibliographicCitation.btitle | Abstract Book 5th Networking World Anesthesia Convention (NWAC) | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Mertens, Karolien; PENNEMANS, Valerie; PENDERS, Joris; SWENNEN, Quirine; VANDER LAENEN, Margot; VANELDEREN, Pascal & BOER, Willem (2014) Pre-ICU characteristics in cardiac surgery patients with CPB developing AKI. In: Abstract Book 5th Networking World Anesthesia Convention (NWAC), p. 13-13. | - |
item.contributor | Mertens, Karolien | - |
item.contributor | PENNEMANS, Valerie | - |
item.contributor | PENDERS, Joris | - |
item.contributor | SWENNEN, Quirine | - |
item.contributor | VANDER LAENEN, Margot | - |
item.contributor | VANELDEREN, Pascal | - |
item.contributor | BOER, Willem | - |
Appears in Collections: | Research publications |
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Online-Abstract-Book.14.pdf | 52.98 kB | Adobe PDF | View/Open |
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