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http://hdl.handle.net/1942/18494
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DC Field | Value | Language |
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dc.contributor.author | KEUNEN, Els | - |
dc.contributor.author | SCHELLINGEN, Kerim | - |
dc.contributor.author | Van Der Straeten, Dominique | - |
dc.contributor.author | REMANS, Tony | - |
dc.contributor.author | COLPAERT, Jan | - |
dc.contributor.author | VANGRONSVELD, Jaco | - |
dc.contributor.author | CUYPERS, Ann | - |
dc.date.accessioned | 2015-03-30T09:04:11Z | - |
dc.date.available | 2015-03-30T09:04:11Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | JOURNAL OF EXPERIMENTAL BOTANY 66(10), p. 2967-2977 | - |
dc.identifier.issn | 0022-0957 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18494 | - |
dc.description.abstract | This study aims to unravel the functional significance of alternative oxidase1a (AOX1a) induction in Arabidopsis thaliana leaves exposed to cadmium (Cd) by comparing wild-type (WT) plants and aox1a knockout mutants. In the absence of AOX1a, differences in stress-responsive transcript and glutathione levels suggest an increased oxidative challenge during moderate (5 µM) and prolonged (72h) Cd exposure. Nevertheless, aox1a knockout leaves showed lower hydrogen peroxide (H2O2) accumulation as compared to the WT due to both acute (24h) and prolonged (72h) exposure to 5 µM Cd, but not to 10 µM Cd. Taken together, we propose a working model where AOX1a acts early in the response to Cd and activates or maintains a mitochondrial signalling pathway impacting on cellular antioxidative defence at the post-transcriptional level. This fine-tuning pathway is suggested to function during moderate (5 µM) Cd exposure while being overwhelmed during more severe (10 µM) Cd stress. Within this framework, ethylene is required – either directly or indirectly via NADPH oxidase isoform C – to fully induce AOX1 expression. In addition, reciprocal crosstalk between these components was demonstrated in leaves of A. thaliana plants exposed to Cd. | - |
dc.description.sponsorship | This work was supported by the Research Foundation Flanders (FWO) through a PhD grant for EK and the project [G0D3414]. Additional funding came from Hasselt University through the Methusalem project [08M03VGRJ] | - |
dc.language.iso | en | - |
dc.rights | © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com | - |
dc.subject.other | alternative oxidase; alternative respiration; Arabidopsis thaliana; cadmium (Cd); ethylene; oxidative challenge | - |
dc.title | ALTERNATIVE OXIDASE1a modulates the oxidative challenge during moderate Cd exposure in Arabidopsis thaliana leaves | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2977 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 2967 | - |
dc.identifier.volume | 66 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | E-mail: ann.cuypers@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/jxb/erv035 | - |
dc.identifier.isi | 000356223900014 | - |
item.contributor | KEUNEN, Els | - |
item.contributor | SCHELLINGEN, Kerim | - |
item.contributor | Van Der Straeten, Dominique | - |
item.contributor | REMANS, Tony | - |
item.contributor | COLPAERT, Jan | - |
item.contributor | VANGRONSVELD, Jaco | - |
item.contributor | CUYPERS, Ann | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2016 | - |
item.fullcitation | KEUNEN, Els; SCHELLINGEN, Kerim; Van Der Straeten, Dominique; REMANS, Tony; COLPAERT, Jan; VANGRONSVELD, Jaco & CUYPERS, Ann (2015) ALTERNATIVE OXIDASE1a modulates the oxidative challenge during moderate Cd exposure in Arabidopsis thaliana leaves. In: JOURNAL OF EXPERIMENTAL BOTANY 66(10), p. 2967-2977. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0022-0957 | - |
crisitem.journal.eissn | 1460-2431 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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J. Exp. Bot.-2015-Keunen-2967-77.pdf | Published version | 1.79 MB | Adobe PDF | View/Open |
JXB_Keunen et al_AOX1a_revised.pdf | Peer-reviewed author version | 1.94 MB | Adobe PDF | View/Open |
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