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Title: The acute cardiorenal syndrome: Burden and mechanisms of disease
Authors: NIJST, Petra 
Mullens, Wilfried 
Issue Date: 2014
Source: Current heart failure reports, 11 (4), p. 453-462
Abstract: Worsening renal function during the treatment of acute decompensated heart failure, so-called acute cardiorenal syndrome, is very common and complicates the treatment course. The underlying pathophysiology of worsening renal function (WRF) involves variable contributions of renal hemodynamics, neurohormonal activity, and oxidative stress. Historically, WRF has been associated with adverse outcomes. However, emerging data support therapeutic strategies that permit WRF while effectively treating congestion as they are associated with improved outcomes.
Keywords: cardiorenal syndrome; worsening renal function; renal dysfunction; heart failure; congestion; central venous pressure; intraabdominal pressure; renal blood flow; renal perfusion
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ISSN: 1546-9549
DOI: 10.1007/s11897-014-0218-4
Rights: © Springer Science+Business Media New York 2014
Category: A3
Type: Journal Contribution
Appears in Collections:Research publications

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