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Title: | Herpes zoster is associated with herpes simplex and other infections in under 60 year-olds | Authors: | OGUNJIMI, Benson Buntinx, Frank Bartholomeeusen, Stefaan Terpstra, Ita De Haes, Inke WILLEM, Lander Elli, Steven Bilcke, Joke Van Damme, Pierre Coenen, Samuel Beutels, Philippe |
Issue Date: | 2015 | Publisher: | W B SAUNDERS CO LTD | Source: | JOURNAL OF INFECTION, 70 (2), p. 171-177 | Abstract: | Objectives: We assessed the association between herpes zoster (HZ) and herpes simplex (HS) occurrence whilst controlling for risk factors of HZ. Methods: Using a Belgian general practitioner network, a retrospective cohort study with 3736 HZ patients and 14,076 age-gender-practice matched controls was performed, covering over 1.5 million patient-years. Multiple logistic regression was used with HZ as outcome and several diagnoses (malignancy, depression, diabetes mellitus, auto-immune diseases, asthma, multiple sclerosis, HIV, fractures), medications (systemic corticosteroids, biologicals, vaccination), HS and other infections as variables. Results: HS was significantly associated with HZ for all analysed time intervals (up to five years) post HZ (OR of 3.51 [2.09 5.88] 95%CI one year post HZ) and to a lesser extent for time ranges pre HZ. Registration of other infections was significantly associated with HZ in all time intervals pre and post HZ (OR up to 1.37). Malignancy up to five years pre HZ, depression up to one year pre or post HZ, fractures up to two years pre HZ, asthma, auto-immune diseases, and immunosuppressive medication one year pre or post HZ were also associated with HZ. Conclusions: HZ and HS occurrences are significantly associated and potentially share a common susceptibility beyond the known risk factors. (C) 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved. | Notes: | [Ogunjimi, Benson; Terpstra, Ita; De Haes, Inke; Willem, Lander; Bilcke, Joke; Beutels, Philippe] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis CHERMID, Vaccine & Infect Dis Inst VAXINFECTIO, B-2610 Antwerp, Belgium. [Ogunjimi, Benson] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, B-3590 Diepenbeek, Belgium. [Buntinx, Frank; Bartholomeeusen, Stephaan; Elli, Steven] Catholic Univ Louvain, Dept Gen Practice & Intego Registry, B-3000 Louvain, Belgium. [Buntinx, Frank] Univ Maastricht, Res Inst Caphri, NL-6229 Maastricht, Netherlands. [Van Damme, Pierre] Univ Antwerp, CEV, Vaccine & Infect Dis Inst VAXINFECTIO, B-2610 Antwerp, Belgium. [Coenen, Samuel] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, B-2610 Antwerp, Belgium. [Coenen, Samuel] Univ Antwerp, Ctr Gen Practice, Vaccine & Infect Dis Inst VAXINFECTIO, B-2610 Antwerp, Belgium. [Beutels, Philippe] Univ New S Wales, Sch Publ Hlth & Community Med, Sydney, NSW 2052, Australia. | Keywords: | Herpes zoster; Herpes simplex; Susceptibility; Influenza;herpes zoster; herpes simplex; susceptibility; influenza | Document URI: | http://hdl.handle.net/1942/18659 | ISSN: | 0163-4453 | e-ISSN: | 1532-2742 | DOI: | 10.1016/j.jinf.2014.08.016 | ISI #: | 000348039900008 | Rights: | © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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