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DC Field | Value | Language |
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dc.contributor.author | LOSADA-PEREZ, Patricia | - |
dc.contributor.author | KHORSHID, Mehran | - |
dc.contributor.author | HERMANS, Chris | - |
dc.contributor.author | Robijns, T. | - |
dc.contributor.author | PEETERS, Marloes | - |
dc.contributor.author | Jimenez-Monroy, K. L. | - |
dc.contributor.author | Truong, L. T. N. | - |
dc.contributor.author | WAGNER, Patrick | - |
dc.date.accessioned | 2015-04-10T12:26:05Z | - |
dc.date.available | 2015-04-10T12:26:05Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | COLLOIDS AND SURFACES B-BIOINTERFACES, 123, p. 938-944 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18669 | - |
dc.description.abstract | In this work we examine the role of lateral phase separation in cholesterol-containing biomimetic membranes on the disrupting action of melittin using a label-free surface-sensitive technique, quartz crystal microbalance with dissipation monitoring (QCM-D). Melittin disruption mechanisms depend strongly on the geometry of the lipid layer; however, despite the interplay between layer geometry/thickness and melittin activity, results indicate that the presence of lipid heterogeneity and lateral phase separation greatly influences the disrupting efficiency of melittin. In homogeneous non-raft forming membranes with high cholesterol content, melittin spontaneous activity is strongly delayed compared to heterogeneous raft-forming systems with the same amount of cholesterol. These results confirm the importance of lateral phase separation as a determinant factor in peptide activity. The information provided can be used for the design of more efficient antimicrobial peptides and the possibility of using a label-free approach for tailored-membranes and interactions with other types of peptides, such as amyloid peptides. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | This work was supported by The Belgian Province of Limburg in the framework of "Life-Science Initiative", the Flemish Government in the framework of the Methusalem project NANO Hasselt-Antwerp, The Research Foundation Flanders FWO, project 6.0B62.13N and Special Research Funds BOF of Hasselt University. The authors thank Prof. Marlies Van Bael for authorizing the use of DLS. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2014 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Melittin; Lipid rafts; Cholesterol; Quartz crystal microbalance with dissipation | - |
dc.subject.other | melittin; lipid rafts; cholesterol; quartz crystal microbalance with dissipation | - |
dc.title | Melittin disruption of raft and non-raft-forming biomimetic membranes: A study by quartz crystal microbalance with dissipation monitoring | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 944 | - |
dc.identifier.spage | 938 | - |
dc.identifier.volume | 123 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Losada-Perez, P.; Khorshid, M.; Hermans, C.; Robijns, T.; Peeters, M.; Jimenez-Monroy, K. L.; Wagner, P.] Hasselt Univ, IMO, B-3590 Diepenbeek, Belgium. [Losada-Perez, P.; Wagner, P.] IMEC Vzw, Div IMOMEC, B-3590 Diepenbeek, Belgium. [Truong, L. T. N.] Hanoi Univ Sci & Technol 1, Sch Engn Phys, Hanoi, Vietnam. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2014.10.048 | - |
dc.identifier.isi | 000347580500118 | - |
item.validation | ecoom 2016 | - |
item.contributor | LOSADA-PEREZ, Patricia | - |
item.contributor | KHORSHID, Mehran | - |
item.contributor | HERMANS, Chris | - |
item.contributor | Robijns, T. | - |
item.contributor | PEETERS, Marloes | - |
item.contributor | Jimenez-Monroy, K. L. | - |
item.contributor | Truong, L. T. N. | - |
item.contributor | WAGNER, Patrick | - |
item.accessRights | Restricted Access | - |
item.fullcitation | LOSADA-PEREZ, Patricia; KHORSHID, Mehran; HERMANS, Chris; Robijns, T.; PEETERS, Marloes; Jimenez-Monroy, K. L.; Truong, L. T. N. & WAGNER, Patrick (2014) Melittin disruption of raft and non-raft-forming biomimetic membranes: A study by quartz crystal microbalance with dissipation monitoring. In: COLLOIDS AND SURFACES B-BIOINTERFACES, 123, p. 938-944. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0927-7765 | - |
crisitem.journal.eissn | 1873-4367 | - |
Appears in Collections: | Research publications |
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losada 1.pdf Restricted Access | Published version | 1.59 MB | Adobe PDF | View/Open Request a copy |
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