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Title: | Photonic studies on polymer-coated sapphire-spheres: A model system for biological ligands | Authors: | MURIB, Mohammed Sharif YEAP, Weng Siang MARTENS, Dries Liu, X. Bienstman, P. Fahlman, M. Schoening, M. J. MICHIELS, Luc HAENEN, Ken Serpenguzel, A. WAGNER, Patrick |
Issue Date: | 2015 | Publisher: | ELSEVIER SCIENCE SA | Source: | SENSORS AND ACTUATORS A-PHYSICAL, 222, p. 212-219 | Abstract: | In this study we show an optical biosensor concept, based on elastic light scattering from sapphire micro-spheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 mu m, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 am, which corresponds to quality factors of approximately 10(5). A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor. (C) 2014 Elsevier B.V. All rights reserved. | Notes: | [Murib, M. S.; Yeap, W. S.; Haenen, K.; Wagner, P.] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Martens, D.; Bienstman, P.] Ghent Univ INTEC, Dept Informat Technol, Photon Res Grp, B-9000 Ghent, Belgium. [Liu, X.; Fahlman, M.] Linkoping Univ, Dept Phys Chem & Biol, S-58183 Linkoping, Sweden. [Schoening, M. J.] Aachen Univ Appl Sci, Inst Nano & Biotechnol, D-52428 Julich, Germany. [Michiels, L.] Hasselt Univ, Biomed Res Inst BIOMED, B-3590 Diepenbeek, Belgium. [Haenen, K.] IMEC VZW, IMOMEC, B-3590 Diepenbeek, Belgium. [Serpenguzel, A.] Koc Univ, Microphoton Res Lab, Dept Phys, TR-34450 Istanbul, Turkey. | Keywords: | label-free biosensor; microcavity; photonics; polydopamine; sapphire microsphere; whispering gallery modes;Label-free biosensor; Microcavity; Photonics; Polydopamine; Sapphire microsphere; Whispering gallery modes | Document URI: | http://hdl.handle.net/1942/18674 | ISSN: | 0924-4247 | e-ISSN: | 1873-3069 | DOI: | 10.1016/j.sna.2014.11.024 | ISI #: | 000349573400025 | Rights: | © 2014 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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