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http://hdl.handle.net/1942/18701
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DC Field | Value | Language |
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dc.contributor.author | Ip, Edward H. | - |
dc.contributor.author | EFENDI, Achmad | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | Bertoni, Alain G. | - |
dc.date.accessioned | 2015-04-14T08:14:35Z | - |
dc.date.available | 2015-04-14T08:14:35Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | BMC MEDICAL RESEARCH METHODOLOGY, 15 | - |
dc.identifier.issn | 1471-2288 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18701 | - |
dc.description.abstract | Background: Epidemiological studies about cardiovascular diseases often rely on methods based on time-to-first-event for data analysis. Without taking into account multiple event-types and the recurrency of a specific cardiovascular event, this approach may underestimate the overall cardiovascular burden of some risk factors, if that is the goal of the study. Methods: In this study we compare four different statistical approaches, all based on the Weibull distribution family of survival model, in analyzing cardiovascular risk factors. We use data from the Cardiovascular Health Study as illustration. The four models respectively are time-to-first-event only, recurrent-events only, multiple-event-types only, and joint recurrent and multiple-event-type models. Results: Although the four models produce consistent results regarding the significance of the risk factors, the magnitude of the hazard ratios and their confidence intervals are different. The joint model produces hazard ratios that are substantially higher than the time-to-first-event model especially for the risk factors of smoking and diabetes. Conclusion: Our findings suggest that for people with diabetes and are currently smoking, the overall cardiovascular burden of these risk factors would be substantially higher than that estimated using time-to-first-event method. | - |
dc.description.sponsorship | The work was partially funded by the Grant R01AG031827A and 1U01HL101066-01 from the National Institute of Health of the United States. | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.rights | © 2015 Ip et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
dc.subject.other | Cardiovascular disease; Cardiovascular risk factor; Survival analysis; Weibull distribution | - |
dc.subject.other | cardiovascular disease; cardiovascular risk factor; survival analysis; Weibull distribution | - |
dc.title | Comparison of risks of cardiovascular events in the elderly using standard survival analysis and multiple-events and recurrent-events methods | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 15 | - |
local.format.pages | 7 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Ip, Edward H.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USA. [Efendi, Achmad] Univ Brawijaya, Dept Math, Programs Stat, Malang 65145, Indonesia. [Molenberghs, Geert] Univ Hasselt, I BioStat, Hasselt, Belgium. [Molenberghs, Geert] Katholieke Univ Leuven, Hasselt, Belgium. [Bertoni, Alain G.] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC 27157 USA. eip@wakehealth.edu | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1186/s12874-015-0004-3 | - |
dc.identifier.isi | 000351198800001 | - |
item.fullcitation | Ip, Edward H.; EFENDI, Achmad; MOLENBERGHS, Geert & Bertoni, Alain G. (2015) Comparison of risks of cardiovascular events in the elderly using standard survival analysis and multiple-events and recurrent-events methods. In: BMC MEDICAL RESEARCH METHODOLOGY, 15. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2016 | - |
item.contributor | Ip, Edward H. | - |
item.contributor | EFENDI, Achmad | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | Bertoni, Alain G. | - |
item.accessRights | Open Access | - |
crisitem.journal.eissn | 1471-2288 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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ip 1.pdf | Published version | 500.98 kB | Adobe PDF | View/Open |
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