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http://hdl.handle.net/1942/18755
Title: | Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis | Authors: | Smolders, Joost PEELEN, Evelyn THEWISSEN, Marielle Menheere, Paul Damoiseaux, Jan Hupperts, Raymond |
Issue Date: | 2014 | Publisher: | SAGE PUBLICATIONS LTD | Source: | MULTIPLE SCLEROSIS JOURNAL, 20 (4), p. 433-437 | Abstract: | Background: A low vitamin D status has been associated with multiple sclerosis (MS). Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP). Objectives: The purpose of this study was to explore whether there is an association between MS and DBP. Methods: We compared DBP concentrations in blood samples of controls (n = 30) and subjects with relapsing-remitting MS (RRMS) during remission (n = 29) and relapse (n = 15). Furthermore, we explored correlations of DBP with 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D levels (1,25(OH)(2)D), and the effect of high-dose vitamin D-3 supplementation on DBP levels in RRMS patients (n = 15). Results: DBP-concentration did not differ between the sub-groups measured, and there was no correlation between DBP and vitamin D metabolite concentration within the physiological range. Upon supplementation of high doses vitamin D-3, DBP concentration remained unaltered. After supplementation, serum 1,25(OH)(2)D(R = 0.517, p = 0.049), but not 25(OH)D, correlated positively with DBP. Conclusions: We found no association between DBP, MS, and vitamin D status within the physiological range. After high - dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism. | Notes: | Corresponding author: Joost Smolders, Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam, 1105BA, The Netherlands. Email: smolders@gmail.com | Keywords: | Multiple sclerosis; vitamin D; vitamin D binding protein;multiple sclerosis; vitamin D; vitamin D binding protein | Document URI: | http://hdl.handle.net/1942/18755 | ISSN: | 1352-4585 | e-ISSN: | 1477-0970 | DOI: | 10.1177/1352458513500552 | ISI #: | 000337295300008 | Rights: | © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
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