Please use this identifier to cite or link to this item:
Title: Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis
Authors: Smolders, Joost
PEELEN, Evelyn 
THEWISSEN, Marielle 
Menheere, Paul
Damoiseaux, Jan
Hupperts, Raymond
Issue Date: 2014
Source: MULTIPLE SCLEROSIS JOURNAL, 20 (4), p. 433-437
Abstract: Background: A low vitamin D status has been associated with multiple sclerosis (MS). Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP). Objectives: The purpose of this study was to explore whether there is an association between MS and DBP. Methods: We compared DBP concentrations in blood samples of controls (n = 30) and subjects with relapsing-remitting MS (RRMS) during remission (n = 29) and relapse (n = 15). Furthermore, we explored correlations of DBP with 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D levels (1,25(OH)(2)D), and the effect of high-dose vitamin D-3 supplementation on DBP levels in RRMS patients (n = 15). Results: DBP-concentration did not differ between the sub-groups measured, and there was no correlation between DBP and vitamin D metabolite concentration within the physiological range. Upon supplementation of high doses vitamin D-3, DBP concentration remained unaltered. After supplementation, serum 1,25(OH)(2)D(R = 0.517, p = 0.049), but not 25(OH)D, correlated positively with DBP. Conclusions: We found no association between DBP, MS, and vitamin D status within the physiological range. After high - dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism.
Notes: Corresponding author: Joost Smolders, Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam, 1105BA, The Netherlands. Email:
Keywords: multiple sclerosis; vitamin D; vitamin D binding protein;Multiple sclerosis; vitamin D; vitamin D binding protein
Document URI:
ISSN: 1352-4585
e-ISSN: 1477-0970
DOI: 10.1177/1352458513500552
ISI #: 000337295300008
Rights: © The Author(s) 2013 Reprints and permissions:
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
Mult Scler-2014-Smolders-433-7.pdf
  Restricted Access
872.72 kBAdobe PDFView/Open    Request a copy
Show full item record


checked on Sep 2, 2020


checked on May 29, 2022

Page view(s)

checked on May 20, 2022


checked on May 20, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.