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DC Field | Value | Language |
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dc.contributor.author | VAN ZWIETEN, Koos Jaap | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | DE BAKKER, Bernadette | - |
dc.contributor.author | KOSTEN, Lauren | - |
dc.contributor.author | DE MUNTER, Stephanie | - |
dc.contributor.author | GERVOIS, Pascal | - |
dc.contributor.author | SCHMIDT, Klaus | - |
dc.contributor.author | LIPPENS, Peter | - |
dc.date.accessioned | 2015-05-27T09:45:46Z | - |
dc.date.available | 2015-05-27T09:45:46Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Knowledge for Growth 2015, FlandersBio's Annual Life Sciences Convention, 11th Edition, Ghent - Belgium, 21/05/2015 | - |
dc.identifier.uri | http://hdl.handle.net/1942/18891 | - |
dc.description.abstract | In order to gain more insight into pathogeneses of joint diseases like Rheumatoid Arthritis (RA) and possibly also Osteoarthritis (OA), High Resolution Magnetic Resonance Imaging (HR-MRI) of the adult proximal interphalangeal (PIP)-joint in an otherwise normal anatomical specimen of the finger was analyzed. We also investigated the histology of a part of the PIP-joint capsule. In adult proximal interphalangeal joints, dorsal and palmar but also ulnar and radial synovial folds (also described as "fat pads" in other synovial joints) do persist, as our HR-MRI slices reveal. Such synovial folds (e.g., after micro-damage) may elicit chronic inflammatory processes that eventually lead to arthritis. In PIP collateral ligaments, we found neurofilaments and oval-shaped lamellated corpuscles (ø ≈ 120 μ). Supposedly acting as mechanoreceptors in finger motion, they may also produce cytokines and substance P, a neuropeptide involved in pain. These organs may also play a role in the pathogeneses of joint inflammation. | - |
dc.language.iso | en | - |
dc.rights | © Knowledge for Growth, FlandersBio, May 21, 2015, Ghent | - |
dc.subject.other | Finger Proximal Interphalangeal (P.I.P.) Joint; Morphogenesis; Arthritis Pathogeneses; Synovial Folds; Synovial Joints Mechanoreceptors; P. I. P. Proper Collateral Ligament (P.C.L.); HR-MRI; Histology. | - |
dc.title | Some morphological substrates in the pathogenesis of arthritis. | - |
dc.type | Conference Material | - |
local.bibliographicCitation.conferencedate | 21/05/2015 | - |
local.bibliographicCitation.conferencename | Knowledge for Growth 2015, FlandersBio's Annual Life Sciences Convention, 11th Edition | - |
local.bibliographicCitation.conferenceplace | Ghent - Belgium | - |
local.bibliographicCitation.jcat | C2 | - |
dc.description.notes | Recent research findings, based on several Master's Theses in Clinical Molecular Sciences from our Group of Functional Morphology, University of Hasselt, Belgium. Knowledge for Growth, FlandersBio, May 21, 2015, Ghent, Program Book Page 16, Therapeutics and Diagnostics - Inflammation, Immunology, Infectious and Eye Diseases : No. 52 | - |
dc.relation.references | 1. de Bakker BS, de Jong KH, Hagoort J, Oostra R-J, Moorman AFM (2012) Towards a 3-dimensional atlas of the developing human embryo: The Amsterdam experience. Reproductive Toxicology, 34, 225-236. 2. Edgar R, Mazor Y, Rinon A, Blumenthal J, Golan Y, Buzhor E, et al. (2013) LifeMap Discovery TM : the embryonic development, stem cells, and regenerative medicine research portal. PLoS One, 8, 7, e66629. 3. Whillis J (1940) The development of synovial joints. Journal of Anatomy, 74, 2, 277-283. 4. Babu KS, Devanandan MS (1995) Sensory receptors situated in the interphalangeal joint capsule of the fingers of the bonnet monkey (Macaca radiata). Acta Anatomica, 153, 1, 49-56. 5. Kallakuri S, Li Y, Chen C, Cavanaugh JM (2012) Innervation of cervical ventral facet joint capsule: Histological evidence. World Journal of Orthopedics, 3, 2, 10-14. | - |
local.type.refereed | Refereed | - |
local.type.specified | Poster | - |
dc.identifier.doi | 10.13140/RG.2.1.1429.2009 | - |
dc.identifier.url | http://knowledgeforgrowth.be/en/research-detail/some-morphological-substrates-in-the-pathogenesis-of-arthritis. | - |
item.contributor | VAN ZWIETEN, Koos Jaap | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | DE BAKKER, Bernadette | - |
item.contributor | KOSTEN, Lauren | - |
item.contributor | DE MUNTER, Stephanie | - |
item.contributor | GERVOIS, Pascal | - |
item.contributor | SCHMIDT, Klaus | - |
item.contributor | LIPPENS, Peter | - |
item.fullcitation | VAN ZWIETEN, Koos Jaap; LAMBRICHTS, Ivo; DE BAKKER, Bernadette; KOSTEN, Lauren; DE MUNTER, Stephanie; GERVOIS, Pascal; SCHMIDT, Klaus & LIPPENS, Peter (2015) Some morphological substrates in the pathogenesis of arthritis.. In: Knowledge for Growth 2015, FlandersBio's Annual Life Sciences Convention, 11th Edition, Ghent - Belgium, 21/05/2015. | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Some morphological substrates in the pathogenesis of arthritis - Knowledge For Growth, K.J. van Zwieten et al., 2015.pdf | Conference material | 144.48 kB | Adobe PDF | View/Open |
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