Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/18996
Title: | Non-vitamin K antagonist oral anticoagulants: considerations on once- vs. twice-daily regimens and their potential impact on medication adherence | Authors: | Vrijens, Bernard HEIDBUCHEL, Hein |
Issue Date: | 2015 | Publisher: | OXFORD UNIV PRESS | Source: | EUROPACE, 17 (4), p. 514-523 | Abstract: | Suboptimal medication adherence is a widespread problem in ambulatory care of chronic diseases, with deviations in either direction from the prescribed dosing regimen. For the non-vitamin Kantagonist oral anticoagulants (NOACs), such deviations occur and can lead to bleeding or clotting, as suboptimal adherence involves temporary periods of either overdosing or underdosing. In this expert review, we discuss: (a) the proper definition of adherence in terms of its three elements: initiation, implementation, and discontinuation; (b) how adherence is reliably and accurately measured and (c) successfully enhanced, to achieve and maintain safe and effective levels of NOAC-based anticoagulation. We also discuss the comparative effects of prescribing the same total daily dose, given either once-daily or as half-strength twice-daily doses. Because NOAC shave plasma half-lives of similar to 12 h, the twice-daily dosing regimen is less prone than the once-daily dosing regimen to hazardously high peaks or hazardously low troughs in anticoagulant concentrations and associated actions. As in other fields of oral drug treatment, the continuity of drug action is greater with twice-daily than with once-daily dosing, despite the fact that a few more doses are skipped with twice-daily than with once-daily dosing. This paradox is explained by the disproportionately greater impact on drug action of skipping a once-daily than a twice-daily dose. Integration of these principles into real-world medication management is the next step in the improvement of oral anticoagulation. | Notes: | [Vrijens, Bernard] MWV Healthcare, B-4600 Vise, Belgium. [Vrijens, Bernard] CHU Sart Tilman, Dept Biostat & Med Informat, B-4000 Liege, Belgium. [Heidbuchel, Hein] Hasselt Univ, B-3500 Hasselt, Belgium. [Heidbuchel, Hein] Jessa Ziekenhuis, Jessa Hosp, Ctr Heart, B-3500 Hasselt, Belgium. | Keywords: | medication adherence; compliance; monitoring; dosing regimens; anticoagulation; new oral anticoagulants; atrial fibrillation; stroke;Medication adherence; Compliance; Monitoring; Dosing regimens; Anticoagulation; New oral anticoagulants; Atrial fibrillation; Stroke | Document URI: | http://hdl.handle.net/1942/18996 | ISSN: | 1099-5129 | e-ISSN: | 1532-2092 | DOI: | 10.1093/europace/euu311 | ISI #: | 000354445400005 | Rights: | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
vrijens 1.pdf Restricted Access | Published version | 457.78 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
94
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
120
checked on Apr 30, 2024
Page view(s)
66
checked on Aug 10, 2022
Download(s)
54
checked on Aug 10, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.