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Title: | Synthesis of a multifunctional poly(p-phenylene ethynylene) scaffold with clickable azidecontaining side chains for (bio)sensor applications | Authors: | BRAEKEN, Yasmine VERSTAPPEN, Pieter LUTSEN, Laurence MAES, Wouter VANDERZANDE, Dirk |
Issue Date: | 2015 | Source: | Polymer Chemistry, 6 (37), 6720-6731 | Abstract: | Poly(p-phenylene ethynylene) (PPE) copolymers with alternating alkoxy and azide-functionalized alkoxy side chains were efficiently synthesized via Sonogashira polymerization and the materials were fully characterized. Among the different synthetic protocols investigated, the best results were obtained when employing a pre-polymerization functionalization approach and upon implementing the azide-functionalized side chains on the diiodophenyl building block. End-capping of the conjugated polymer chains is shown to be essential for preventing side reactions. As a proof of principle, phenylacetylene is clicked in a nearly quantitative way on the polymer backbone. Furthermore, successful click-immobilization of randomly alkynylated protein A onto an azide-functionalized PPE film illustrates the potential use of these materials in a variety of (bio)sensor applications. | Notes: | Maes, W (reprint author), Hasselt Univ, Inst Mat Res IMO IMOMEC, DSOS, Agoralaan 1,Bldg D, B-3590 Diepenbeek, Belgium wouter.maes@uhasselt.be | Document URI: | http://hdl.handle.net/1942/19092 | ISSN: | 1759-9954 | e-ISSN: | 1759-9962 | DOI: | 10.1039/c5py00741k | ISI #: | 000361207600015 | Rights: | This journal is © The Royal Society of Chemistry 2015 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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