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http://hdl.handle.net/1942/19131
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DC Field | Value | Language |
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dc.contributor.author | DHAEZE, Tessa | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | Liston, Adrian | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.date.accessioned | 2015-09-11T08:51:10Z | - |
dc.date.available | 2015-09-11T08:51:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | AUTOIMMUNITY REVIEWS, 14 (8), p. 735-741 | - |
dc.identifier.issn | 1568-9972 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19131 | - |
dc.description.abstract | Regulatory T cells (Tregs) are essential in maintaining tolerance to self. Several lines of evidence indicate that Tregs are functionally impaired in a variety of autoimmune diseases, leading to inefficient regulation of autoimmune T cells. Recent findings also suggest that Tregs are essential in controlling autoreactive B cells. The recently identified follicular regulatory T cell subset (T-FR) is thought to regulate the production of autoantibodies in the germinal center (GC) response. Here we provide an update on the role of Tregs in controlling the GC response, and whether defective control over B cell tolerance contributes to autoimmunity. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | Funding from IUAP, FWO and BOF were obtained for the preparation of this article. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2015 Elsevier B.V. All rights reserved. | - |
dc.subject.other | regulatory T cells; humoral autoimmune disease; follicular T cells; B cells; germinal center response; circulating follicular regulatory T cells | - |
dc.subject.other | Regulatory T cells; Humoral autoimmune disease; Follicular T cells; B cells; Germinal center response; Circulating follicular regulatory T cells | - |
dc.title | Humoral autoimmunity: A failure of regulatory T cells? | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 741 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 735 | - |
dc.identifier.volume | 14 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Onderzoeksinst, Diepenbeek, Belgium. [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Liston, Adrian] VIB, Autoimmune Genet Lab, Leuven, Belgium. [Liston, Adrian] Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/j.autrev.2015.04.006 | - |
dc.identifier.isi | 000357243600011 | - |
item.fullcitation | DHAEZE, Tessa; STINISSEN, Piet; Liston, Adrian & HELLINGS, Niels (2015) Humoral autoimmunity: A failure of regulatory T cells?. In: AUTOIMMUNITY REVIEWS, 14 (8), p. 735-741. | - |
item.accessRights | Restricted Access | - |
item.contributor | DHAEZE, Tessa | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | Liston, Adrian | - |
item.contributor | HELLINGS, Niels | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2016 | - |
crisitem.journal.issn | 1568-9972 | - |
crisitem.journal.eissn | 1873-0183 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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dhaeze 1.pdf Restricted Access | Published version | 746.97 kB | Adobe PDF | View/Open Request a copy |
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