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http://hdl.handle.net/1942/19133
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DC Field | Value | Language |
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dc.contributor.author | HANSEN, Dominique | - |
dc.contributor.author | LINSEN, Loes | - |
dc.contributor.author | VERBOVEN, Kenneth | - |
dc.contributor.author | HENDRIKX, Marc | - |
dc.contributor.author | RUMMENS, Jean-Luc | - |
dc.contributor.author | VAN ERUM, Monique | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.contributor.author | DENDALE, Paul | - |
dc.date.accessioned | 2015-09-11T10:45:54Z | - |
dc.date.available | 2015-09-11T10:45:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | EXPERIMENTAL PHYSIOLOGY, 100 (7), p. 818-828 | - |
dc.identifier.issn | 0958-0670 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19133 | - |
dc.description.abstract | New Findings What is the central question of this study? It remains uncertain whether significant fat-free mass wasting occurs early after coronary artery bypass graft surgery, and the aetiology of this wasting in these particular conditions is unexplored. What is the main finding and its importance? Significant fat-free mass wasting is present after coronary artery bypass graft surgery, and this wasting effect is greater in younger patients and in patients with greater increments in blood cortisol-to-testosterone ratios after surgery. The magnitude and aetiology of muscle wasting early after coronary artery bypass graft (CABG) surgery remains unknown. In the present study, we assessed changes in fat-free mass early after CABG surgery and explored the possible aetiology (relationships with postsurgical changes in blood hormones, insulin resistance, subject characteristics and inflammation) for these changes. Fat-free mass was assessed before and 23(range: 25)days after CABG surgery in 25 subjects. Blood testosterone, cortisol, insulin-like growth factor-1, growth hormone, sex hormone-binding globulin, glucose, insulin, C-peptide and C-reactive protein concentrations were determined, and free androgen index, cortisol-to-testosterone ratio and HOMA-IR index were all calculated before surgery, during the first 3days after surgery and at reassessment of body composition. Relationships between changes in fat-free mass and changes in blood parameters after surgery or subject characteristics were studied. After surgery, free androgen index and blood sex hormone-binding globulin, testosterone and insulin-like growth factor-1 concentrations decreased significantly, while HOMA-IR index, cortisol-to-testosterone ratio, blood growth hormone, insulin and C-reactive protein concentrations increased significantly (P<0.0025, observed >0.80). Whole-body fat-free mass decreased significantly [by -1.9(range: 9.1)kg, P<0.0025, observed =0.99] after surgery. According to regression analysis, greater absolute loss of fat-free mass was observed after CABG surgery in subjects who were younger, who experienced a greater increase in blood cortisol-to-testosterone ratio after surgery and/or who underwent earlier reassessment of body composition (P<0.05). Significant decrements in fat-free mass were observed early after CABG surgery, especially in younger subjects and/or subjects with elevated blood cortisol-to-testosterone ratios after surgery. Interventions to preserve fat-free mass soon after CABG surgery are thus warranted. | - |
dc.description.sponsorship | This study was supported by an unrestricted research grant from Hartcentrum Hasselt vzw. L.L. is part of the 'Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa', supported by the foundation Limburg Sterk Merk, province of Limburg, Flemish government, Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital. | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.rights | © 2015 The Authors. Experimental Physiology © 2015 The Physiological Society | - |
dc.title | Magnitude of muscle wasting early after on-pump coronary artery bypass graft surgery and exploration of aetiology | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 828 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 818 | - |
dc.identifier.volume | 100 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Hansen, Dominique; Linsen, Loes; Verboven, Kenneth; Hendrikx, Marc; Rummens, Jean-Luc; van Erum, Monique; Eijnde, Bert O.; Dendale, Paul] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Ctr, REVAL Rehabil Res Ctr, B-3590 Diepenbeek, Belgium. [Hansen, Dominique; Dendale, Paul] Jessa Hosp, Heart Ctr Hasselt, Hasselt, Belgium. [Linsen, Loes; Rummens, Jean-Luc] Univ Biobank Limburg, Hasselt, Belgium. [Linsen, Loes; Rummens, Jean-Luc] Jessa Hosp, Lab Expt Hematol, Hasselt, Belgium. [Hendrikx, Marc] Jessa Hosp, Dept Cardiothorac Surg, Hasselt, Belgium. | - |
local.publisher.place | HOBOKEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1113/EP085053 | - |
dc.identifier.isi | 000357300600008 | - |
item.contributor | HANSEN, Dominique | - |
item.contributor | LINSEN, Loes | - |
item.contributor | VERBOVEN, Kenneth | - |
item.contributor | HENDRIKX, Marc | - |
item.contributor | RUMMENS, Jean-Luc | - |
item.contributor | VAN ERUM, Monique | - |
item.contributor | OP 'T EIJNDE, Bert | - |
item.contributor | DENDALE, Paul | - |
item.validation | ecoom 2016 | - |
item.fullcitation | HANSEN, Dominique; LINSEN, Loes; VERBOVEN, Kenneth; HENDRIKX, Marc; RUMMENS, Jean-Luc; VAN ERUM, Monique; OP 'T EIJNDE, Bert & DENDALE, Paul (2015) Magnitude of muscle wasting early after on-pump coronary artery bypass graft surgery and exploration of aetiology. In: EXPERIMENTAL PHYSIOLOGY, 100 (7), p. 818-828. | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0958-0670 | - |
crisitem.journal.eissn | 1469-445X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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hansen 1.pdf Restricted Access | Published version | 475.93 kB | Adobe PDF | View/Open Request a copy |
peer.pdf | Peer-reviewed author version | 652.09 kB | Adobe PDF | View/Open |
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