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http://hdl.handle.net/1942/19135
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DC Field | Value | Language |
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dc.contributor.author | Van de Putte, Gregg | - |
dc.contributor.author | OBEN, Jolien | - |
dc.contributor.author | PRENEN, Leen | - |
dc.contributor.author | Schobbens, Jean Christophe | - |
dc.contributor.author | Vlasselaer, Jos | - |
dc.contributor.author | Van Holsbeke, Caroline | - |
dc.contributor.author | DEBROCK, Guy | - |
dc.contributor.author | Van Eycken, Peter | - |
dc.contributor.author | DE JONGE, Eric | - |
dc.date.accessioned | 2015-09-14T08:34:35Z | - |
dc.date.available | 2015-09-14T08:34:35Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 25 (6), p. 993-999 | - |
dc.identifier.issn | 1048-891X | - |
dc.identifier.uri | http://hdl.handle.net/1942/19135 | - |
dc.description.abstract | Introduction The standard treatment of ovarian cancer is the combination of debulking surgery and chemotherapy. There is an ongoing discussion on which treatment is best: primary debulking surgery (PDS) or neoadjuvant chemotherapy with interval debulking (NACT-IDS). Even a large randomized trial has not settled this issue. We examined whether comparing a specified treatment protocol would not be a more logical approach to answer this type of discussions. Methods A retrospective study of 142 consecutively treated patients according to a fixed protocol between 2000 and 2012 was conducted. Disease-free survival and overall survival were calculated by univariate and multivariate analyses for the whole group and for advanced stages separately. Specific differences between PDS and NACT-IDS were studied. Comparison of results from large databases was made. Results Disease-free survival and overall 5-year survival for the whole group were 35% and 50%. For the advanced stages, disease-free survival and overall 5-year survival were 14% and 36%, with a median disease-free and overall survival of 16 and 44 months. Of the 98 women with advanced ovarian carcinoma, 54% of operable patients underwent PDS and 44% underwent NACT-IDS. More patients in the PDS group were optimally (<1 cm) debulked: 80% vs 71%. There was no significant difference in survival between PDS or NACT-IDS. Optimally debulked patients had a significant better overall survival in multivariate analysis with a hazard ratio of 2.1. Discussion Outcome of treatment according to a fixed protocol with a mixture of PDS and NACT-IDS was similar to results from large databases. We hypothesize that comparison of a specific strategy may yield more useful results than awaiting the perfect randomized trial. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | © 2015 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology. | - |
dc.subject.other | Ovarian carcinoma; Surgery; Neoadjuvant chemotherapy; Survival; Strategy | - |
dc.subject.other | ovarian carcinoma; surgery; neoadjuvant chemotherapy; survival; strategy | - |
dc.title | Outcome of Epithelial Ovarian Cancer Time for Strategy Trials to Resolve the Problem of Optimal Timing of Surgery | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 999 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 993 | - |
dc.identifier.volume | 25 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Van de Putte, Gregg; Oben, Jolien; Schobbens, Jean Christophe; Vlasselaer, Jos; Van Holsbeke, Caroline; de Jonge, Eric] Ziekenhuis Oost Limburg, Dept Gynecol, Genk, Belgium. [Prenen, Leen] Univ Hasselt, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Debrock, Guy] Ziekenhuis Oost Limburg, Dept Oncol, Genk, Belgium. [Van Eycken, Peter] Ziekenhuis Oost Limburg, Dept Pathol, Genk, Belgium. | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1097/IGC.0000000000000461 | - |
dc.identifier.isi | 000357286900008 | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2016 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Van de Putte, Gregg; OBEN, Jolien; PRENEN, Leen; Schobbens, Jean Christophe; Vlasselaer, Jos; Van Holsbeke, Caroline; DEBROCK, Guy; Van Eycken, Peter & DE JONGE, Eric (2015) Outcome of Epithelial Ovarian Cancer Time for Strategy Trials to Resolve the Problem of Optimal Timing of Surgery. In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 25 (6), p. 993-999. | - |
item.contributor | Van de Putte, Gregg | - |
item.contributor | OBEN, Jolien | - |
item.contributor | PRENEN, Leen | - |
item.contributor | Schobbens, Jean Christophe | - |
item.contributor | Vlasselaer, Jos | - |
item.contributor | Van Holsbeke, Caroline | - |
item.contributor | DEBROCK, Guy | - |
item.contributor | Van Eycken, Peter | - |
item.contributor | DE JONGE, Eric | - |
crisitem.journal.issn | 1048-891X | - |
crisitem.journal.eissn | 1525-1438 | - |
Appears in Collections: | Research publications |
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Outcome_of_Epithelial_Ovarian_Cancer__Time_for.8.pdf Restricted Access | 212.67 kB | Adobe PDF | View/Open Request a copy |
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