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http://hdl.handle.net/1942/19149
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DC Field | Value | Language |
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dc.contributor.author | DHAEZE, Tessa | - |
dc.contributor.author | PEELEN, Evelyn | - |
dc.contributor.author | Hombrouck, Anneleen | - |
dc.contributor.author | PEETERS, Liesbet | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | LEMKENS, Nele | - |
dc.contributor.author | LEMKENS, Peter | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.contributor.author | Lucas, Sophie | - |
dc.contributor.author | BROUX, Bieke | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.date.accessioned | 2015-09-15T09:27:31Z | - |
dc.date.available | 2015-09-15T09:27:31Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY, 195 (3), p. 832-840 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19149 | - |
dc.description.abstract | Follicular regulatory T cells (T-FR) have been extensively characterized in mice and participate in germinal center responses by regulating the maturation of B cells and production of (auto) antibodies. We report that circulating T-FR are phenotypically distinct from tonsil-derived T-FR in humans. They have a lower expression of follicular markers, and display a memory phenotype and lack of high expression of B cell lymphoma 6 and ICOS. However, the suppressive function, expression of regulatory markers, and FOXP3 methylation status of blood T-FR is comparable with tonsil-derived T-FR. Moreover, we show that circulating T-FR frequencies increase after influenza vaccination and correlate with anti-flu Ab responses, indicating a fully functional population. Multiple sclerosis (MS) was used as a model for autoimmune disease to investigate alterations in circulating T-FR. MS patients had a significantly lower frequency of circulating T-FR compared with healthy control subjects. Furthermore, the circulating T-FR compartment of MS patients displayed an increased proportion of Th17-like T-FR. Finally, T-FR of MS patients had a strongly reduced suppressive function compared with healthy control subjects. We conclude that circulating T-FR are a circulating memory population derived from lymphoid resident T-FR, making them a valid alternative to investigate alterations in germinal center responses in the context of autoimmune diseases, and T-FR impairment is prominent in MS. | - |
dc.description.sponsorship | This work was supported by Bijzonder Onderzoeksfonds, Fonds Wetenschappelijk Onderzoek, Interuniversitaire Attractiepolen, and Methusalem. | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.rights | Copyright © 2015 by The American Association of Immunologists, Inc. All rights reserved. | - |
dc.title | Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 840 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 832 | - |
dc.identifier.volume | 195 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Dhaeze, Tessa; Peelen, Evelyn; Peeters, Liesbet; Van Wijmeersch, Bart; Somers, Veerle; Broux, Bieke; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Dhaeze, Tessa; Peelen, Evelyn; Peeters, Liesbet; Van Wijmeersch, Bart; Somers, Veerle; Broux, Bieke; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. [Hombrouck, Anneleen] Sci Inst Publ Hlth, Viral Dis Unit, Operat Direct Transmitted & Infect Dis, B-1200 Brussels, Belgium. [Van Wijmeersch, Bart] Rehabil & Multiple Sclerosis Ctr, B-3900 Overpelt, Belgium. [Lemkens, Nele; Lemkens, Peter] Hosp East Limburg, B-3600 Genk, Belgium. [Lucas, Sophie] Catholic Univ Louvain, de Duve Inst, B-1200 Brussels, Belgium. | - |
local.publisher.place | BETHESDA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.4049/jimmunol.1500759 | - |
dc.identifier.isi | 000358070400013 | - |
item.validation | ecoom 2016 | - |
item.contributor | DHAEZE, Tessa | - |
item.contributor | PEELEN, Evelyn | - |
item.contributor | Hombrouck, Anneleen | - |
item.contributor | PEETERS, Liesbet | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | LEMKENS, Nele | - |
item.contributor | LEMKENS, Peter | - |
item.contributor | SOMERS, Veerle | - |
item.contributor | Lucas, Sophie | - |
item.contributor | BROUX, Bieke | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | HELLINGS, Niels | - |
item.accessRights | Restricted Access | - |
item.fullcitation | DHAEZE, Tessa; PEELEN, Evelyn; Hombrouck, Anneleen; PEETERS, Liesbet; VAN WIJMEERSCH, Bart; LEMKENS, Nele; LEMKENS, Peter; SOMERS, Veerle; Lucas, Sophie; BROUX, Bieke; STINISSEN, Piet & HELLINGS, Niels (2015) Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis. In: JOURNAL OF IMMUNOLOGY, 195 (3), p. 832-840. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0022-1767 | - |
crisitem.journal.eissn | 1550-6606 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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J Immunol-2015-Dhaeze-832-40.pdf Restricted Access | 1.96 MB | Adobe PDF | View/Open Request a copy |
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